Muktadir Shahid Hossain is an Associate Professor of the Department of Biochemistry and Microbiology of NSU. He joined the department in Janauary 2017.
Muktadir S. Hossain completed his Ph.D. at the University of Tokyo, Japan in 2004 where he showed that quiescent (G0) phase cells of multicellular eukaryotes like mammals and insects require DNA topoisomeras II enzyme for the re-entry into the cell cycle, whereas the unicellular eukaryotes like yeast do not. The title of his Ph.D. dissertation is "Requirement for DNA topoisomerase II during the G0-to-S phase transition in mammalian and insect cells". In the University of Tokyo as a Ph.D. student, he participated in the isolation of temperature-sensitive mutants of the pathogenic bacterium, Staphylococcus aureus. In the University of Tokyo as a Ph.D. student, he also showed that the DNA double-strand break-inducing drugs that are used to treat cancner can induce myogenic differentiation in cultured cells of the fruit fly, Drosophila melanogaster. In the University of Tokyo as a Research Assistant, he established the larvae of the silk moth, Bombyx mori as animal model to study purified toxins from pathogenic bacteria like S. aureus and Pseudomonas aeruginosa by injection. He joined the National Cancer Institute (NCI) of National Institutes of Health (NIH) in Bethesda, Maryland, USA as a post-doctoral fellow where he identified certain transcription factors that regulate initiation of embryonic muscle differentiation in D. melanogaster. Then, he joined the Shanghai Institutes of Biological Sciences, China as a Senior Research Fellow to show that the evolutionarily conserved transcription factor, FoxO is required for the activation of ecdysone signaling during starvation for better survival of larvae of both B. mori and D. melanogaster. In Andong National University, South Korea, he showed as a Visiting Fellow along with other researchers that the ICA69 gene is a cytosolic phospholipase A2 that participates in the immunity of the beet armyworm, Spodoptera exigua, an important pest insect. As a Research Professor in Chonbuk National University, South Korea, he introduced the CRISPR-Cas9 gene-editing technique in the pest insect-killing fungus, Beauveria bassiana which is useful not only to identify the molecular mechanism of pathogenicity of B. bassiana towards insect pests by gene knock-out but also to improve the pathogenicity of the fungus by overexpressing virulence genes. Since B. bassiana is harmless to humans but can kill pest insects efficiently, it can be used in the context of Bangladesh where the use of chemical pesticides is widespread to control insect pests to increase crop production in an environmentally friendly way.