Dr. Md. Ashraful Alam

Full Time Faculty
Assistant Professor

B.Pharm (Hons.), MS in Pharmacology, PhD (UQ, Australia)

Phone: +880-2-55668200 Ext: 1963
Email: ashraful.alam@northsouth.edu
Office: SAC 949

Curriculum Vitae

I am Dr Md Ashraful Alam, currently serving as an Assistant Professor of Department of Pharmaceutical Sciences, North South University Bangladesh. I obtained B.Pharm (Hons.) from Pharmacy Discipline, Khulna University in 2004. I also completed MS In Pharmacology from Bangladesh Agricultural University, Mymensingh in June,  2006. I was awarded PhD degree from The University of Queensland, Australia on May, 2013. My PhD research work  focused on the understanding of the causes of obesity and related cardiovascular complications. To understand this process, we used diet induced obese rat model. We measured the development of vascular dysfunction and cardiac remodeling along with other parameters of metabolic syndrome. We also used pure natural antioxidant to evaluate their preventive nature against obesity development and efficacy in our obese rat model and tried to understand the mechanism of action in molecular level. A good number of articles have been published from my research work at UQ.
Now, we have several animal models for studying oxidative stress and related organ dysfunctions. We are also trying to find out the cures for these oxidative stress related complications from natural sources.

BOOK, BOOK CHAPTER AND REVIEWS

2016

  1. Md Ashraful Alam, Nusrat Subhan, Hemayet Hossain, Murad Hossain, Hasan Mahmud Reza, Md Mahbubur Rahman, M Obayed Ullah (2016) Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity.  BMC Nutrition and Metabolism 13:27.
  2. Md Abu Taher Sagor, Md. Mohabbulla Mohib, Md. Shafiul Azam, Anisur Rahman, Foysal Tareq Tanmoy, Wahida Khan Chowdhury, Nafees Uddin Chowdhury, Hasan Mahmud Reza and Md Ashraful Alam (2016) Angiotensin-II, a potent peptide, participates in the development of hepatic dysfunctions", Immunology Endocrine & Metabolic Agents in Medicinal Chemistry, Vol 16 (Accepted). DOI: 10.2174/1871522217666170106103001.
  3. Mohib M Md, Hasan I, Chowdhury WH, Chowdhury NU, Mohiuddin S, Sagor MAT, Reza HM and Alam MA, Role of Angiotensin II in hepatic inflammation through MAPK pathway: A review. J Hepatology. 2016, 2:2.
  4. Nafees Uddin Chowdhury, Tasdik Farooq, Shahanshah Abdullah, Ahmed Shohrawar Mahadi, Md Mehedee Hasan, Tasfiq Zaman Paran, Nahid Hasan, Md Mohabbulla Mohib, Md Abu Taher Sagor and Md Ashraful Alam (2016) Matrix Metalloproteinases (MMP), a Major Responsible Downstream Signaling Molecule for Cellular Damage – A Review,
  5. Sarif Mohiuddin, Shahida Arbee, Md. Mohabbulla Mohib, Md. Moshfequr Rahman, Md. Abu Taher Sagor and Md. Ashraful Alam (2016) Role of oxidative stress on diabetic nephropathy and some anti-oxidant mediated treatment strategies with their mechanism -a review. Word Journal of Pharmaceutical Research, 5(2): 135-145.

2015

Md Ashraful Alam, Riaz Uddin, Nusrat Subhan, Md Mahbubur Rahman, Preeti Jain and Hasan Mahmud Reza (2015) Beneficial role of Bitter melon supplementation on obesity and related complications in metabolic syndrome, Journal of Lipids, Article ID 496169, 18 pages, 2015. doi:10.1155/2015/496169.

2014

  1. Md. Ashraful Alam, Nusrat Subhan, Md Mahbubur Rahman, Shaikh J Uddin, Hasan M Reza and Satyajit D Sarker (2014) Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action, Advances in Nutrition 5(4):404-417.
  2. Md Ashraful Alam and Md Mahbubur Rahman (2014) Mitochondrial dysfunction in obesity: potential benefit and mechanism of Co-enzyme Q10 supplementation in metabolic syndrome, BMC Journal of Diabetes and Metabolic Disorder 13:60.

2012

  1. Md. Ashraful Alam, Shaikh Jamal Uddin, Lindsay Brown (2012) Mitogen-activated protein kinase and natural phenolic compounds in cardiovascular remodeling, Studies in Natural Product Chemistry 38:159-190. (e-Book chapter). doi: 10.1016/B978-0-444-59530-0.00006-X.
  2. Riaz Uddin, Nadia Saffoon, Md. Ashraful Alam (2012) Protein Binding Interaction: Effect of arsenic on three NSAIDs binding with BSA. (Book published by LAMBERT Academic Publishing).

2012

  1. Riaz Uddin, Nadia Saffoon, Md. Ashraful Alam (2011) Arsenic, the poison and poisoned groundwater of Bangladesh: A review. International Current Pharmaceutical Journal 1(1): 12-17.

 

List of Publications of Research Articles

2016

  1. Anayt Ulla, Md Tariqur Rahman, Zaki Farhad Habib, Md. Moshfequr Rahman, Nusrat Subhan, Biswajit Sikder, Hasan Mahmud Reza,  Md Hemayet Hossain, Md Ashraful Alam (2016) Mango peel powder supplementation prevents oxidative stress, inflammation and fibrosis in carbon tetrachloride induced hepatic dysfunction in rats, Journal of Food Biochemistry (Accepted).
  2. Syed Yeasin Arafat, Mohammad Nayeem, Sharfiat Jahan, Zarifa Karim, Hasan Mahmud Reza, Md Hemayet Hossain, Mohammad Shohel, Md Ashraful Alam  (2016) Ellagic acid rich Momordica charantia fruit pulp supplementation prevented oxidative stress, fibrosis and inflammation in liver of alloxan induced diabetic                                                                                                                                                          rats. Oriental Pharmacy and Experimental Medicine (2016) 16: 267. doi:10.1007/s13596-016-0242-x.
  3. Md Abu Taher Sagor, Hasan Mahmud Reza, Nabila Tabassum, Biswajit Sikder, Anayt Ulla, Nusrat Subhan, Md Hemayet Hossain and Md Ashraful Alam (2016) Supplementation of rosemary (Rosmarinus officinalis) prevents oxidative stress, inflammation, fibrosis, & iron overload on CCl4 treated rat’s model, Current Nutrition and Food Science, Vol 12; DOI  10.2174/1573401312666160816154610.
  4. Saleh R, Zahid ZI, Rahman MA, Jain P, Alam A, Reza HM, Kawaichi M (2016) Prevalence of PPAR-γ2 (rs1801282), RETN (rs3745367) and ADIPOQ (rs2241766) SNP markers in the Bangladeshi type 2 diabetic population. Meta Gene. (Accepted).
  5. Subash Pandaya, Razwa Saleh, Md. Ashraful Alam, Md. Mamun Al-Amin, Preeti Jain and Hasan Mahmud Reza (2016) Interleukin-6 gene polymorphism (-572 C>G) in Type 2 diabetes of Bangladeshi origin, Advances in Biological Research 10 (3): 167-174.
  6. Hasan Mahmud Reza, Nabila Tabbasum, Md Abu Taher Sagor, Md Mahbubur Rahman, Preeti Jain, Md Ashraful Alam (2016) Angiotensin converting enzyme inhibitor prevented oxidative stress, inflammation and fibrosis in liver of carbon tetrachloride (CCl4) treated rats, Toxicology Mechanisms and Methods. 26(1): 45-53. http://dx.doi.org/10.3109/15376516.2015.112495.

 

2015

  1. Md Ashraful Alam,  Mohammed Riaz Hasan Chowdhury,  Preeti Jain,  Md Abu Taher Sagor,  Hasan Mahmud Reza (2015) DPP-4 inhibitor sitagliptin prevents inflammation and oxidative stress of heart and kidney in two kidney and one clip (2K1C) rats, BMC Diabetology And Metabolic Syndrome, 7: 107.
  2. Md. Abu Taher Sagor, Md. Golam Rabbi, Md. Moshfequr Rahman, Monirul Islam, Md. Tariqur Rahman, Md. Mohabbulla Mohib, Md. Mahidur Rahman Khan and Md. Ashraful Alam (2015) Chronic kidney disease might lead to hepatic dysfunction on 2K1C treated rats -a histological evaluation, Word Journal of Pharmaceutical Research, 4(11): 1939-1956.
  3. Hasan Mahmud Reza, Zarin Tasnim Gias, Priota Islam, Sadia Sabnam, Preeti Jain, Md Hemayet Hossain, Md Ashraful Alam (2015) HPLC-DAD system based phenolic content analysis and in vitro anti-oxidant activities of rice bran obtained from Aush Dhan (Oryza sativa) of Bangladesh, Journal of Food Biochemistry, 39 (4): 462-470.
  4. Md Abu Taher Sagor, Nabila Tabassum, Md Abdullah Potol and Md Ashraful Alam (2015) Xanthine oxiadase inhibitor, Allopurinol, prevented oxidative stress, fibrosis and myocardial damage in isoproterenol induced aged rats. Oxidative Medicine and Cellular Longevity (2015) (2015), Article ID 478039.
  5. Mohammed Riaz Hasan Chowdhury, Md Abu Taher Sagor, Nabila Tabassum, Md Abdullah Potol, Hemayet Hossain and Md Ashraful Alam (2015) Supplementation of Citrus maxima peel powder prevented oxidative stress, fibrosis and hepatic damage in carbon tetrachloride (CCl4) treated rats, Evidence-Based Complementary and  Alternative Medicine, 2015 (2015), Article ID 598179.
  6. Md Abu Tahel Sagor, Mohammed Riaz Hasan Chowdhury, Nabila Tabassum, Hemayet Hossain, Md Mahbubur Rahman and Md Ashraful Alam
    (2015) Supplementation of fresh bitter melon (Ucche) prevented oxidative stress, fibrosis and hepatic damage in CCl4 treated rats. BMC Complementary and Alternative Medicine, 15:115.
  7. Hasan Mahmud Reza, Md Abu Taher Sagor, Md Ashraful Alam (2015) Iron deposition causes oxidative stress, inflammation and fibrosis in carbon tetrachloride (CCl4) induced liver dysfunction in rats. Bangladesh Journal of Pharmacology, 10: 152-59.
  8. Preeti Jain, MA Akbar Hossain; K Fatema;  KU Mazumder; MS Hossain;  Hemayet Hossain; Md Ashraful Alam, Hasan Mahmud Reza (2015) Antinociceptive and anti-inflammatory activities of Mycetia longifolia (Wall.) O. Kuntze. Journal of Herbs Spices and Medicinal Plants 21(3): 321-331.

2014

  1. Preeti Jain, MA Akbar Hossain; K Fatema;  KU Mazumder; MS Hossain;  Hemayet Hossain; Md Ashraful Alam, Hasan Mahmud Reza (2014) Anti-inflammatory, analgesic and antioxidant activities of Allophylus cobbe Leaves. Amarican Journal of Pharmacology and Toxicology 9 (4): 220-228.
  2. Md. Mamun Al-Amin, Nageeb Hasan, Tanzir Alam, Ahmed Tasdid Hasan, Imran Hossain, Rohini Rowshan Didar, Md. Ashraful Alam, Md. Mahbubur Rahman (2014) Tadalafil enhances working memory, and reduces hippocampal oxidative stress in both young and aged mice. European Journal of Pharmacology, 745:84-90.
  3. Nadia Saffoon, Riaz Uddin, Nusrat Subhan, Hemayet Hossain, Hasan Mahmud Reza, Md. Ashraful Alam (2014) In vitro anti-oxidant activity and HPLC-DAD system based phenolic content analysis of Codiaeum variegatum found in Bangladesh Advanced Pharmaceutical Bulletin 4(Suppl 2), 533-541.
  4. Riaz Uddin, Moni Rani Saha, Nusrat Subhan, Hemayet Hossain, Ismet Ara Jahan, Raushanara Akter, Md. Ashraful Alam (2014) HPLC-analysis of polyphenolic compounds in Gardenia jasminoides and determination of antioxidant activity by using free radical scavenging assays. Advanced Pharmaceutical Bulletin 4(3):273-81.
  5. Riaz Uddin, Raushanara Akter, S.M. Raquibul Hasan, Ehsanul Hoque Mazumder, Md. Ashraful Alam (2014) In vitro free radical scavenging and membrane stabilizing activity of Paederia foetida leaves. Journal of Pharmaclogical and Toxicological Studies 2(1):21-28.

2013

  1. Md. Ashraful Alam, Kathleen Kauter, Kerry Withers, Conrad Sernia, Lindsay Brown (2013) Chronic L-arginine improves the metabolic, cardiovascular, and liver complications in diet-induced obesity in rats. Food and Function 4: 83-91 DOI: 10.1039/C2FO30096F.
  2. Md. Ashraful Alam, Kathleen Kauter, Lindsay Brown (2013) Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats. Nutrients 5: 637-650.

 2012

  1. Md. Ashraful Alam, Conrad Sernia, Lindsay Brown (2012) Ferulic acid improves cardiovascular and kidney structure and function in hypertensive rats. J Cardiovasc Pharmacol. 61:240–249. DOI: 10.1097/FJC.0b013e31827cb600.
  2. Fatema Zohura Talukder, Kousik Ahmed Khan, Riaz Uddin, Nusrat Jahan, Md. Ashraful Alam (2012) In vitro free radical scavenging and anti-hyperglycemic activities of Achyranthes aspera extract on alloxan induced diabetic mice. Drug Discoveries & Therapeutics 6(6):298-305.
  3. Isabelle Cameron, Md. Ashraful Alam, Jianxiong Wang, and Lindsay Brown: (2012) Endurance exercise training in a rat model of the metabolic syndrome. Canadian Journal of Physiology and Pharmacology 90 (11): 1490-1497.  DOI 10.1139/y2012-097.
  4. Riaz Uddin, Nadia Saffoon, Md. Ashraful Alam (2012) Effect of arsenic on paracetamol binding to bovine serum albumin using site specific probes. International Current Pharmaceutical Journal 1(11): 361-365.

2011

  1. Abishek Iyer, Kathleen Kauter, Md. Ashraful Alam, Christophe Morisseau, Bruce D Hammock and Lindsay Brown (2011) Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats, Experimental Diabetes Research, DOI:10.1155/2012/758614.
  2. Panchal SK, Poudyal H, Iyer A, Nazer R, Alam MA, Diwan V, Kauter K, Sernia C, Campbell F, Ward L et al (2011) High-carbohydrate high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats. J Cardiovasc Pharmacol 57(1):51-64.
  3. Shazid Md. Sharker, Ahmed Ayedur Rahman and Md. Ashraful Alam (2011). Identification and characterization of the binding sites of amitriptyline on bovine serum albumin. Insight Pharmaceutical Sciences, 1:24-28. DOI: 10.5567/IPHARMA-IK.2011.24.28.
  4. N. Subhan, R. Habibur, A. Ashraful, I. Rashedul, R. Mahbubur (2011) Relationship between protein-binding and free drug concentrations of a sparingly water-soluble selective serotonin reuptake inhibitors (escitalopram) and its interaction with arsenic. Rom. J. Biophys. 21(2):139-149.
  5. Alam MA, Subhan N, Chowdhury SA, Awal MA, Mostofa M, Rashid MA, Hasan CM, Nahar L, Sarker SD (2011) Anthocephalus cadamba (Roxb.) Miq., Rubiaceae, extract shows hypoglycemic effect and eases oxidative stress in alloxan-induced diabetic rats. Revista Brasileira de Farmacognosia 21: 155-164. doi: 10.1590/S0102-695X2011005000033. 

2010

  1. Nadia Safoon, Md Ashraful Alam, Golam Mezbah Uddin (2010) Phytochemical and cytotoxic investigation of Codiaeum variegatum Linn leaves. Stamford Journal of Pharmaceutical Sciences, 3(2):51-53.
  2. S. M. Raquibul Hasan, Md. Mokarram Hossain, Raushanara Akter,  Md. Ehsanul Hoque Mazumder, Md. Ashraful Alam, Abdullah Faruque , and Shafiqur Rahman (2010) Analgesic activity of the different fractions of the aerial parts of Commelina benghalensis Linn. International Journal of Pharmacology. 6(1): 63-67.

2009

  1. Md Ashraful Alam,  Nusrat Subhan,  Md Mostafizur Rahman,  Kamaluddin Ahmed,  Abdul Ghani,  SM Raquibul Hasan,  Md Mokarram Hossain,  Raushanara Akter,  Muntasir Mamun Majumder, (2009) Antinociceptive and gastro-protective effect of the ethanolic extract of the flowering top of Anthocephalus Cadamba Roxb. Oriental Pharmacy and Experimental Medicine 9(12):326-334.
  2. Moni Rani Saha; M. Ashraful Alam; S. M. Raquibul Hasan; Md. Mokarrom Hossain; Raushanara Akter, Ehsanul Hoque Mazumder Md. Sohel Rana (2009)  In- vitro anti-oxidant activity of the leaves of Dillenia indica. Oriental Pharmacy and Experimental Medicine 9(12):277-284.
  3. Moni Rani Saha, S.M. Raquibul Hasan, Raushanara Akter, Md. Mokarram Hossain, Md.Shohidul Alam, Md. Ashraful Alam, M. Ehsanul Hoque Mazumder (2009) In vitro Free radical scavenging activity of methanol extract of the leaves of Mimosops elengi Linn. Bangladesh Journal of Veterinary Medicine 6(2): 197-202.
  4. Alam, M. A., Subhan, N., Awal, M. A., Alam, M. S., Sarder, M., Nahar, L. and Sarker, S. D. (2009) Antinociceptive and anti-inflammatory properties of Ruellia tuberose. Pharmaceutical Biology.  47(3): 209–214.
  5. Mohammed Ehsanul Hoque Mazumder, Badrul Alam, Md. Ashraful Alam, Mariam Jamila, Mohammed Didare Alam Muhsin (2009) Investigations of secondary Metabolites, antioxidant and cytotoxic activities of the leaf extract of Portuleca oleracea L.  Bangladesh Journal of Life Sciences, 21(1): 17-22.
  6. MA Alam; MA Awal; N Subhan; M Mostofa (2009 Feb) In-vitro relationship between protein binding and free drug concentrations of a water-soluble selective ß-adrenoreceptor antagonists (atenolol) and its interaction with arsenic. Journal of Health Population and Nutrition 27(1):20-30.
  7. M. Ashraful Alam, M. Mostafizur Rahman, Nusrat Subhan, M. Muntasir Majumder, S M Raquibul Hasan, Raushanara Akter, M. Ehsanul Haque Mazumder, Abdullah Faruque (2009) Antioxidant potential of the ethanolic crude extract of the leaves of Vitex negundo Linn. (Verbenaceae). Turkish Journal of Pharmaceutical Sciences 6 (1):11-20.

2008

  1. SM Raquibul Hasan, Mariam Jamila, Muntasir Mamun Majumder, Raushanara Akter, Md. Mokarram Hossain, Md. Ehsanul Hoque Mazumder, Md. Ashraful Alam, Rumana Jahangir, Md. Sohel Rana, Md. Arif and Shafiqur Rahman (2008) Analgesic and antioxidant activity of the hydromethanolic extract of Mikania scandens (L.) Willd. Leaves. American Journal of Pharmacology and Toxicology 4(1):1-7.
  2. SM Raquibul Hasan, Md. Mokarram Hossain, Abdullah Faruque, Md. Ehsanul Hoque Mazumder, Md. Sohel Rana, Raushanara Akter, Md. Ashraful Alam. (2008) Comparison of antioxidant potential of different fractions of Commelina benghalensis Linn. Bangladesh Journal of Life Sciences 20(2):9-16.
  3. Raushanara Akter, SM Raquibul Hasan, Abdullah Faruque, Ehsanul Hoque Mazumder, Moni Rahi Saha, Muntasir Mamun Majumder, Md. Ashraful Alam, Md. Mokarram Hossain (2008) Dissolution study of some commercially available sustained release Diclofenac sodium tablet dosage forms. Bangladesh Journal of Life Sciences 21(1):143-146.
  4. Nusrat Subhan, Md. Ashraful Alam, Firoj Ahmed, Ishrat Zahan Shahid. (2008) Antinociceptive and Gastroprotective effect of the Crude Ethanolic Extracts of Excoecaria agallocha. Turkish Journal of Pharmaceutical Sciences 5 (3):143-154.
  5. Md. Ashraful Alam, Md. Abdul Awal, Nusrat Subhan, Md. Mahmudul Hasan Sikder, S. M. Mahbubul Alam, Mahbub Mostofa,  Saikh Jamal Uddin (2008) Studies of in-vitro amlodipine and arsenic displacement interaction at binding sites of bovine serum albumin. Iranian Journal of Pharmacology and Therapeutics. 7(1):1-8.
  6. Nusrat Subhan, Md. Ashraful Alam, Firoj Ahmed, Israt Jahan Shahid, Lutfun Nahar, Satyajit Dey Sarker (2008) Bioactivity of Excoecaria agallocha. Brazilian Journal of Pharmacognosy, 18(4): 521-526.
  7. Raushanara Akter, S.M. Raquibul Hasan, Samira Ayesha Siddiqua, Muntasir Mamun Majumder, Md. Mokarram Hossain, Md. Ashraful Alam, Shamsul Haque, Abdul Ghani (2008) Evaluation of analgesic and antioxidant potential of the leaves of Curcuma alismatifolia Gagnep. Stamford journal of Pharmaceutical Sciences 1(1, 2): 3-9.
  8. Md. Ashraful Alam, Nazmuj Slahin, Riaz Uddin, S.M. Raquibul Hasan, Raushanara Akter,  Abdul Ghani (2008) Analgesic and neuropharmacological investigations of the aerial parts of Achyranthes aspera Linn. Stamford Journal of Pharmaceutical Sciences. 1(1& 2): 44-51.
  9. Muntasir M. Majumder, Ehsanul H. Mazumder, M. Ashraful Alam, Raushanara Akter, Mostafizur Rahman, Satyajit D. Sarker (2008) Antioxidant and membrane stabilizing properties of Ichnocarpus frutescens. Journal of Natural Remedies 8(1):209-215.
  10. Mohammed Ehsanul Hoque Mazumder, Badrul Alam, Md. Ashraful Alam, Mariam Jamila, Mohammad Obayed Ullah, Mohammed Didare Alam Muhsin (2008) DPPH free radical scavenging and brine shrimp lethality bioassay of Enhydra fluctuans leaf extract. South East University Journal of Science.  1(1):26-31.
  11. M. Ashraful Alam, Raushanara Akter, Nusrat Subhan, M. Mostafizur Rahman, Muntasir M. Majumder, Lutfun Nahar, Satyajit D. Sarker, (2008) Antidiarrhoeal property of the hydroethanolic extract of the flowering tops of Anthocephalus cadamba. Brazilian Journal of Pharmacognosy, 18(2): 155-159.
  12. Moni Rani Saha, Md. Ashraful Alam, Raushanara Akter,  Rumana Jahangir (2008) In-vitro free radical scavenging activity of Ixora coccinea L, Bangladesh Journal of Pharmacology, 3(2): 90-96.
  13. Md. Ashraful Alam, Riaz Uddin and Shamsul Haque. (2008) Protein binding interaction of warfarin and acetaminophen in presence of arsenic and of the biological system. Bangladesh J Pharmacol.  3(2): 49-54.
  14. Subhan N, Alam M A, Ahmed F, Awal MA, Nahar L and Sarker SD. (2008) In vitro antioxidant property of the extract of Excoecaria agallocha (Euphorbiaceae), DARU 16(3) : 149-154.
  15. Alam MA, Ghani A, Subhan N, Rahman MM, Haque MS, Majumder MM, Mazumder MEH, Akter RA, Nahar L and Sarker SD (2008) Antioxidant and membrane stabilizing properties of the flowering tops of Anthocephalus cadamba. Natural Product Communications.  3(1):65-70.
  16. MA Alam, MAB Nyeem,  MA Awal, M Mostofa, MS Alam, N Subhan, M. Mostafizur Rahman  (2008) Antioxidant and hepatoprotective action of the crude methanolic extract of the flowering top of Rosa damascena. Oriental Pharmacy and Experimental Medicine. 8(2):164-170.
  17. MA Alam, N. Subhan, MA Awal, MS Alam, KA. Daulla (2008) Anti-inflammatory and anti-noceceptive action of the crude extracts of Costus specious on rodents, Oriental Pharmacy and Experimental Medicine.  8(3):243-251.

2007

  1. Alam MA, Awal MA, Subhan N, Daulla KA (2007) Sedative for nuropharmacological and antinoceceptive effect of the crude methanolic extract of Xylocarpus granatum on mice. Nigerian Journal of Natural Product and Medicine. 11: 53-57.
  2. Md Ashraful Alam, Md. Abdul Awal,  Mahbub Mostofa, Md. Kamrul Islam, Nusrat Subhan  (2007) In-vitro displacement interaction of atenolol and amlodipine on binding with bovine serum albumin when co administered. Bangladesh J. Pharmacol. 2(10):20-26.

2006

  1. MA Alam, M Sarder, MA Awal, MMH Sikder and KA Daulla (2006). Antibacterial activity of the crude ethanolic extract of Xylocarpus granatum. Bangladesh Journal of Veterinary Medicine. 4(1): 69-72.
  2. MA Alam, M.E Haque, JA Shilpi and KA Daulla (2006) Antinociceptive effect of the crude ethanolic extract of Crataeva nurvala. Buch on mice. Bangladesh Journal of Veterinary Medicine. 4(1): 65-68.
  3. Mohammad Ashraful Alam, Md Abu bin Nyeem, Md. Abdul Awal,  Mahbub Mostofa, Nusrat Islam and Sheikh Jamal Uddin (2006) CNS depressant effect of the crude methanolic extract of Rosa damascene on mice. Iranian Journal of Pharmacology and Therapeutics. 5(2): 171-174.

2005

  1. SJ Uddin, R Rouf, PK Sen, MA Alam, MM Sarder, JA Shilpi and SK Sadhu (2005) In-vitro studies of the effect of arsenic on the binding of metronidazole at the binding sites of bovine serum albumin. Khulna University Studies. 6(2): 73-76.

2004

  1. SJ Uddin, JA Shilpi, GMM Murshid, AA Rahman, MM Sarder and MA Alam (2004) Determination of the binding sites of arsenic on bovine serum albumin using warfarin (site-I specific probe) and diazepam (site-II specific probe). Journal of Biological Sciences. 4(5):609-612.

 

PRESENTATION & PROCEEDINGS

 

1)   Md. Abdullah Al Mamun, Md. Faruk, Md. Mizanur Rahman, Kamrun Nahar,  Fariha Kabir, Hasan Mahmud Reza and Md. Ashraful Alam, (2016) Psidium guajava leaf powder supplementation prevents metabolic syndrome and oxidative stress in liver of high carbohydrate high fat diet induced obese rats. Poster presented in National Conference on Biochemistry and Molecular Biology for Life Sciences 2016, Organized by The Bangladesh Society for Biochemistry and Molecular Biology, December 10, 2016.

2)   Fariha Mamun, Usran Ferdous, Md Mizanur Rahman, Dr Hasan Mahmud Reza, Dr Md Ashraful Alam (20016) Dried Amalaki (Emblica officinalis) powder prevents oxidative stress and fibrosis in two kidney one clip (2K1C) model rats. Poster presented in National Conference on Biochemistry and Molecular Biology for Life Sciences 2016, Organized by The Bangladesh Society for Biochemistry and Molecular Biology, December 10, 2016.

3)   Mohammad Nazmul Alam, Md. Mizanur Rahman, Anayt Ulla, Murad Hossain,                  Hasan Mahmud Reza, Md Ashraful Alam. (2016) Evaluation of Astaxanthin in Isoprenaline Induced Cardiac Remodeling in Aged Rats. Poster presented in National Conference on Biochemistry and Molecular Biology for Life Sciences 2016, Organized by The Bangladesh Society for Biochemistry and Molecular Biology, December 10, 2016.

4)   Md. Mizanur Rahman, Mohammad Nazmul Alam, Anayt Ulla, Hemayet Hossain,               Md. Ashraful Alam and  Hasan Mahmud Reza (20016) Phenolic content analysis of Psidium guajava leaves powder by HPLC-DAD system and In vivo cardioprotective and antioxidant activity in FCA induced rats. Poster presented in National Conference on Biochemistry and Molecular Biology for Life Sciences 2016, Organized by The Bangladesh Society for Biochemistry and Molecular Biology, December 10, 2016.

5)   Kamrun Nahar, Fariha kabir, Md Mizanur Rahman, Dr Md Ashraful Alam (2016) Beet root (Beta vulgaris) powder supplementation prevents oxidative stress and inflammatory cell infiltration in isoprenaline induced myocardium damage in rats. Poster presented in National Conference on Biochemistry and Molecular Biology for Life Sciences 2016, Organized by The Bangladesh Society for Biochemistry and Molecular Biology, December 10, 2016.

6)   Fariha Kabir, Towheed Ul Islam, Waresa Sadeque Sananda, Shejuti Islam, Tahsin Zahan, Md Mizanur Rahman, Anayt Ulla, Md Ashraful Alam, Hasan Mahmud Reza (2016) Evaluation of L-carnitine in isoproterenol induced cardiac remodeling in aged rats. Oral presented in National Conference on Biochemistry and Molecular Biology for Life Sciences 2016, Organized by The Bangladesh Society for Biochemistry and Molecular Biology, December 10, 2016.

7)   Syed Mustyen Quader, Dr. Murad Hossain, Md Mizanur Rahman, Dr Hasan Mahmud Reza, Dr Md Ashraful Alam (2016) Effect of superoxide dismutase mimetic, tempol, on carbon tetrachloride induced hepatic inflammation and fibrosis in the liver of rats. Oral presented in National Conference on Biochemistry and Molecular Biology for Life Sciences 2016, Organized by The Bangladesh Society for Biochemistry and Molecular Biology, December 10, 2016.

8)   Trisha Khan , Md Mizanur Rahman , Anayt Ullah , Mohammad Nazmul Alam , Bishwajit Sikder  and Md Ashraful Alam (2016) Cardamom powder supplementation prevents obesity, improves glucose intolerance, inflammation and oxidative stress in liver of high carbohydrate high fat diet induced obese rats. Endocrine Society's 98th Annual Meeting and Expo, April 1– 4, 2016 ­ Boston.

9)   Anayet Ullah,  Biswajit Sikder, Md Mizanur Rahman, Farzana Akther Sumi, Mostafe Khalid, Md Hemayet Hossain, Hasan Mahmud Reza,  and Md Ashraful Alam (2016) Supplementation of Eugenia jambolena seed powder prevented obesity, glucose intolerance, hyperlipidemia and oxidative stress in high carbohydrate high fat diet induced obese rats. Poster presented (Md Mizanur Rahman) in 3rd National Conference on Natural Science and Technology (NCNST'16), which was held at Asian University for Women (AUW, Chittagong, Bangladesh) during April 15-16, 2016.

10)              Mohammad Nazmul Alam, Md. Mizanur Rahman, Anayt Ulla, Nusrat Subhan, Hasan Mahmud Reza, Murad Hossain, Md Ashraful Alam (2016) Effect of astaxanthin on oxidative stress and cardiac remodeling in isoproterenol administered aged rats. Oral presentation (by Mohammad Nazmul Alam) presented in 3rd National Conference on Natural Science and Technology (NCNST'16), which was held at Asian University for Women (AUW, Chittagong, Bangladesh) during April 15-16, 2016.

11)              Farzana Akther Sumi, Umme Nahida Islam, Biswajit Kumer Sikder, Md Ashraful Alam, Hasan Mahmud Reza (2016) Protective effect of antioxidant rich ethanolic extract of Citrus maxima Merr. fruit peels against carotid artery occlusion induced ischemia/reperfusion in brain of mice. Poster presented (by Farzana Akther Sumi) in 3rd National Conference on Natural Science and Technology (NCNST'16), which was held at Asian University for Women (AUW, Chittagong, Bangladesh) during April 15-16, 2016.

12)              Razwa Saleh, Preeti Jain, Md. Ashraful Alam, Hasan Mahmud Reza (2016) Prevalence of PPAR-γ2 (RS1801282), RETN (RS3745367) and ADIPOQ (RS2241766) SNP markers in the Bangladeshi diabetic population. Poster presented (Razwa Saleh) in 5th Biennial Conference of DASG (Diabetes in Asia Study Group) on the 16th and 17th April, 2016.

13)              Alam, M. A., Ward, L., Withers, K. and Brown, L. (2011). Mitochondrial function is altered in rats fed a high carbohydrate, high fat diet. In: Proceedings of the Nutrition Society of Australia (2011). Joint Annual Scientific Meeting of the Nutrition Society of New Zealand and the Nutrition Society of Australia, Queenstown, New Zealand, (103-103). 29 November - 2 December 2011. 

14)              Md. Ashraful Alam, Lindsay Brown (2011) Chronic administration of L-arginine and co-enzyme-Q10 attenuates cardiometabolic syndrome in diet induced obese rat, potential role on obesity. Abstract submitted for poster presentation in ASMR Post graduate student Conference and medical research awards on 2nd June 2011.

15)              Md. Ashraful Alam, Lindsay Brown (2011) Phenolic acids improve cardiovascular structure and function in diet-induced obese wistar rats. Abstract published in Journal of Pharmaceutical Sciences and poster presentation in the 11th Southeast Asian Western Pacific regional meeting of pharmacologists (cancelled due to earthquake, tsunami and nuclear threat).

16)              Md. Ashraful Alam, Lindsay Brown (2010) Ferulic acid improves endothelial function and cardiovascular remodelling in nitric oxide-deficient rats. Abstract published and poster presented in Gold Coast Medical Research Conference 2010.

17)              Md. Ashraful Alam, Abishek Iyer, Hemant Poudyal, Sunil Panchal, Lindsay Brown (2010) Cardiac and endothelial dysfunction are improved in high carbohydrate, high fat fed  rats with the antioxidant, ferulic acid. Abstract published and poster presentation in Post Graduate Student Conference 10th June 2010 organized at School of Biomedical Sciences, UQ.

18)              Md. Ashraful Alam, Vijay Mor, Lindsay Brown (2010) Structural and morphological changes in endocrine pancreas in high fat high carbohydrate fed rats treated with ferulic acid. Abstract published and poster presentation in ASMR Post graduate student Conference and medical research awards on 2nd June 2010 organized at Institute for Molecular Bioscience, UQ.

19)              CNS depressant effect of the crude methanolic extract of Rosa damascene on mice. Presented and abstract published in 12th Annual Scientific Conference of BSVER organized in 31 December, 2005, Bangladesh Agricultural University, Mymensingh 2202.

20)              Studies of in-vitro amlodipine and arsenic displacement interaction at binding sites of bovine serum albumin. Presented and abstract published in 13th Annual Scientific Conference of BSVER organized in 17-18 February, 2007, Bangladesh Agricultural University, Mymensingh 2202.

21)              Antioxidant and membrane stabilizing properties of Codiaeum variegatum leaf Extracts. Presented and abstract published in 14th Annual Scientific Conference of BSVER organized in 9-10 February, 2008, Bangladesh Agricultural University, Mymensingh 2202.

 

  1. Ministry of Science and Technology, Bangladesh R & D project research grant 2016-1017 as a Principal Investigator.
  2. NSU internal Research grant 2016-1017 as a Principal Investigator
  3. Best Poster Presenter Awards (as a team leader) from 4th AYUNS international Conference 2016.
  4. Ministry of Science and Technology, Bangladesh R & D project research grant 2015-1016 as a Principal Investigator.
  5. Ministry of Science and Technology, Bangladesh special allocation grant for research 2015-2016 as a Co-Investigator.
  6. Dean’s Award 2016 from School of Health and Life Sciences, North South University, Bangladesh for outstanding research performance.
  7. Travel Awards for Joint Annual Scientific Meeting of the Nutrition Society of New Zealand and the Nutrition Society of Australia 2011.
  8. Islamic Development Bank Three Years Merit PhD Scholarship-2009-2012.
  9. University of Queensland International Research Tuition Awards 2009-2012.
  10. University Scholarship at Graduate Level (MS in Pharmacology) from Bangladesh Agricultural University Bangladesh 2005-2006.
  11. Grants for thesis preparation from Bangladesh Agricultural University, Bangladesh, 2006.

NO

DEGREE

INSTITUTION

YEAR

AWARD/GRADE

1

PhD

School of Biomedical Sciences, The University of Queensland, St. Lucia, QLD, Australia.

2013

Awarded

2

MS in Pharmacology

Department of Pharmacology; Faculty of Veterinary Science. Bangladesh Agricultural University, Mymensingh.

2006

Grade-A

GPA-3.906/4

3

B Pharm. (Hons.)

Pharmacy Discipline, Life Science School, Khulna University, Bangladesh

 

2003

First Class, % of marks obtained-67.07%

4

Higher Secondary Certificate Examination

Khulna Public College, Khulna.

 

1998

Science, First Division, % of marks obtained-70.30%

 

5

Secondary School Certificate Examination

Chalna K.C. Pilot High School, Chalna, Khulna

1996

Science, First Division, % of marks obtained-79.60%

 

Academic Career

  1. Assistant Professor, Department of Pharmaceutical Sciences, North-South University Bangladesh (24-05-2014 to date).
  2. Assistant Professor (Part Time), Department of Pharmaceutical Sciences, North-South University Bangladesh (02-08-2013 to 23-05-2014).
  3. Casual academic staff, School of Biomedical Sciences, The University of Queensland 2009, 2012, 2013.
  4. Lecturer, Department of Pharmacy, Faculty of Science, Stamford University Bangladesh. 02-05-2013 to 05-02-2009; February, 2009 to June, 2013 (on Study Leave)

RESEARCH WORK DONE IN UDERGRADUATE AND POST GRADUATE LEVEL

1)             “Role of natural antioxidants and phenolic compounds in cardiometabolic syndrome” for the fulfillment of the degree PhD (Biomedical Science), The University of Queensland. Supervised by Professor Lindsay Brown, Department of Biological and Physical Sciences, University of Southern Queensland, Australia.

2)             “Protein binding nature of the antihypertensive drugs (atenolol and amlodipine) and drug- drug interaction in presence of arsenic” for the partial fulfillment of the degree MS in Pharmacology from Bangladesh Agricultural University. Supervised by Professor Dr. Md Abdul Awal, Department of Pharmacology, Bangladesh Agricultural University, Mymensingh.

3)             “Pharmacological investigation of the crude extract of the plant Xylocarpus granatum” for the Partial fulfillment of the degree Bachelor of Pharmacy (Hons.) from Khulna University, Bangladesh. Supervised by Assoc. Professor Mokaddez Sarder, Pharmacy Discipline, Khulna University.

Expertise:

  1. Langendorff heart preparation and Ischemic conditioning.
  2. Organ bath for thoracic aorta and rat ileum.
  3. Non-invasive tail-cuff blood pressure measurement in rat.
  4. Animal model studied- diet induced obese rat model, L-NAME induced hypertensive rat model, DOCA-salt induced hypertensive rat model, spontaneously hypertensive rat model, neuropathic pain model, aortic banding for cardiac hypertrophy.
  5. Histological process- tissue processing, sectioning, slide preparation and staining for heart, liver, kidney and pancreas. Normal architecture and special staining for fibrosis and inflammatory cells, insulin positive area and islets size etc.
  6. Antioxidant enzyme assay for SOD and catalase, Gpx, fluorescence assay for ROS etc.
  7. Western blot for eNOS, heme oxygenase, MAPKs etc.
  8. Mitochondrial isolation, respiration, proton leak and membrane potential assay.
  9. Laser scanning confocal microscopy, fluorescence microscopy etc.
  10. In-vitro antioxidant assays for natural compound.
  11. Cell culture, MTT assay, functional TNF-alpha production assay.
  12. Statistics software, Prism, SPSS.
None
Currently teaching
Undergraduate level
Pharmacology I; Organic Pharmacy II; Pharmaceutical Microbiology I and Pharmacognosy
Graduate Level
Toxicology and Safety Pharmacology

PROFESSIONAL MEMBERSHIP

  1. Graduate Pharmacist Association, Bangladesh
  2. Canadian Society of Basic and Clinical Pharmacology
  3. Bangladesh Society for Basic Experimental Pharmacology and Therapeutics.
  4. Nutrition society Australia, 2010-2011
  5. Australian Society for Medical Research, 2010-2011
REVIEW REQUEST PERFORMED FOR
  1. BMC Complementary and Alternative Medicine
  2. Journal of Dietary Supplements
  3. Karger Pharmacology
  4. African Journal of Complementary and Alternative Medicine.
  5. Iranian Journal of Pharmacology and Therapeutics.
  6. Oriental Pharmacy and Experimental Medicine.
  7. Journal of Herbs Spices and Medicinal Plants.
  8. Medicinal Chemistry Communications, Royal Society of Chemistry Journal.
  9. Associate editor- Stamford Journal of Pharmaceutical Sciences, 2009.
My lab (under my leadership) is currently doing research on several projects.
1. CCl4 induced cirrhotic liver in rats.
2. 2K1C Goldblatt hypertensive rat model.
3. ISO induced cardiac remodeling in rats.
4. High fat diet induced obesity in rats and natural compounds.
we are currently using Red amaranth (Lal shak), Rice bran, Guava leaves as well as ramipril, sitagliptin, etorocoxib as therapeutic intervention for inflammation and oxidative stress on those experimental model.
Figure: ISO induced cardiac remodeling in rat heart.




Figure: CCl4 induced liver fibrosis and inflammation in rats.
Full Time Faculty
Assistant Professor

B.Pharm (Hons.), MS in Pharmacology, PhD (UQ, Australia)

Phone: +880-2-55668200 Ext: 1963
Email: ashraful.alam@northsouth.edu
Office: SAC 949

Curriculum Vitae