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Full Time Faculty Director, NSU Genome Research Institute (NGRI) Associate Professor Ph. D. (Bioinformatics and Computational Biology), University of Nottingham, UK Phone: +880-2-55668200 Ext: 1903 Email: muhammad.maqsud@northsouth.edu; mdmaqsud0@gmail.com Curriculum Vitae |
I am currently the Director of country’s first ever genome research center, NSU Genome Research Institute (NGRI) and also Associate Professor of the Dept of Biochemistry and Microbiology. I was one of the founding faculty members of the Department and also working as an honorary consultant in developing and implementing future projects of a Bangladesh-based Research Unit of Johns Hopkins Bloomberg School of Public Health in the Global Network for maternal and child health. A scientist with over a decade of specialism in bioinformatics, genomics and molecular microbiology and extensive experience gained by working at the renowned University of Nottingham, A star Genome Institute of Singapore where I was a central part of the analysis, interpretation and writing of the genome sequencing projects involving RNA editing pattern in different human diseases such as cancer and effect of this biological process in the developmental processes of human and other animals. This experience was built on through research at University of Nottingham (eg. Emes and Hossain, BMC Genomics, 2015), icddr,b., Moredun Research Institute and training at European Bioinformatics Institute, Cambridge, University College London, and Birmingham University. Recent interests of my group are comparative genomics to understand gene function and evolution and functional genomics. Significance and impact of our research has been through creation of original analysis tools and comprehensive interpretation of complex biological data enabling challenging research to be undertaken. Our identification of the lack of a coherent capability in complex biological/biomedical data analysis drove the creation of the NSU Genome Research Institute (NGRI) in May, 2017. Under my co-direction NGRI has since secured funding and looking for potential grant opportunities in collaboration with other national and international institutes such as University of Maryland, Pennsylvania State University, Johns Hopkins Bloomberg School of Public Health, University of Nottingham, IIIT Delhi and many others. The research works of NGRI has already been resulted in few publications in international journals and the Institute has also established the infrastructure for biobanking and genetic analysis around 50,000 samples from different stages of pregnancy to identify potential genetic and epigenetic markers for intervention of different maternal, neonatal and child health related adverse conditions.
1. Mobarak AM, Miguel E, Abaluck J, Ahuja A, Alsan M, Banerjee A, Breza E, Chandrasekhar AG, Duflo E, Dzansi J, Garrett D, Goldsmith-Pinkham P, Gonsalves GS, Hossain MM, Jakubowski A, Kang G, Kharel A, Kremer M, Meriggi N, Nekesa C, Olken BA, Omer SB, Qadri F, Rees H, Salako B, Voors M, Warren S, Więcek W. End COVID-19 in low- and middle-income countries. Science. 2022 Mar 11;375(6585):1105-1110. doi: 10.1126/science.abo4089. Epub 2022 Mar 10. PMID: 35271319.
2. Jason A, Laura HK., Ashley S, Ashraful H, Alamgir K, Ellen BJ, Emily C, Jade B-C, Shabib R, Shadman R, Salim B, Neeti Z, Peter J. W., Maqsud H, Hasan MR,Abdullah J, Shawkee GM, Aura R, Faika LB, Tahrima SH, Stephen PL, Ahmed MM. Impact of community masking on COVID-19: A cluster-randomized trial in Bangladesh. Science.abi9069 (2021). dOi: 10.1126/science.abi9069
3. Hossain M, Tabassum T, Rahman A, Hossain A, Afroze T, Momen AMI, Sadique A, Sarker M, Shams F, Ishtiaque A, Khaleque A, Alam M, Huq A, Ahsan GU, Colwell RR. Genotype-phenotype correlation of β-lactamase-producing uropathogenic Escherichia coli (UPEC) strains from Bangladesh. Sci Rep. 2020 Sep 3;10(1):14549. doi: 10.1038/s41598-020-71213-5.
4. Jain P, Bepari AK, Sen PK, Rafe T, Imtiaz R, Hossain M, Reza HM. High prevalence of multiple antibiotic resistance in clinical E. coli isolates from Bangladesh and prediction of molecular resistance determinants using WGS of an XDR isolate. Sci Rep. 2021 Nov 24;11(1):22859. doi: 10.1038/s41598-021-02251-w. PMID: 34819576; PMCID: PMC8613203.
5. Shirin T, Akramb A, Hasan S, Rahman A, Sultana S, Alam AN, Khan M H, Hossain S, Flora M S, Hossain M, Analysis and identification of genomic and immunogenic features of dengue serotype 3 genomes obtained during the 2019 outbreak in Bangladesh,New Microbes and New Infections. 2022 July. doi.org/10.1016/j.nmni.2022.100996.
6. Khan S, Akter S, Goswami B, Habib A, Banu TA, Barton C, Osman E, Samir S, Arjuman F, Hasan S, Hossain M. Whole genome mapping and identification of single nucleotide polymorphisms of four Bangladeshi individuals and their functional significance. BMC Res Notes. 2021 Mar 20;14(1):105. doi: 10.1186/s13104-021-05514-x.
7. Rahman A, Bhuiyan OF, Sadique A, Afroze T, Sarker M, Momen AMI, Alam J, Hossain A, Khan I, Rahman KF, Kamruzzaman M, Shams F, Ahsan GU, Hossain M. Whole genome sequencing provides genomic insights into three Morganella morganii strains isolated from bovine rectal swabs in Dhaka, Bangladesh. FEMS Microbiol Lett. 2020 Mar 1;367(6):fnaa043. doi: 10.1093/femsle/fnaa043.
8. Zaman NR, Chowdhury UF, Reza RN, Chowdhury FT, Sarker M, Hossain MM, Akbor MA, Amin A, Islam MR, Khan H. Plant growth promoting endophyte Burkholderia contaminans NZ antagonizes phytopathogen Macrophomina phaseolina through melanin synthesis and pyrrolnitrin inhibition. PLoS One. 2021 Sep 30;16(9):e0257863. doi: 10.1371/journal.pone.0257863.
9. Ahmed F, Islam MA, Kumar M, Hossain M, Bhattacharya P, Islam MT, Hossen F, Hossain MS, Islam MS, Uddin MM, Islam MN, Bahadur NM, Didar-Ul-Alam M, Reza HM, Jakariya M. First detection of SARS-CoV-2 genetic material in the vicinity of COVID-19 isolation Centre in Bangladesh: Variation along the sewer network. Sci Total Environ. 2021 Jul 1;776:145724. doi: 10.1016/j.scitotenv.2021.145724
10. Bhattacharya P, Kumar M, Islam MT, Haque R, Chakraborty S, Ahmad A, Niazi NK, Cetecioglu Z, Nilsson D, Ijumulana J, van der Voorn T, Jakariya M, Hossain M, Ahmed F, Rahman M, Akter N, Johnston D, Ahmed KM. Prevalence of SARS-CoV-2 in Communities Through Wastewater Surveillance-a Potential Approach for Estimation of Disease Burden. Curr Pollut Rep. 2021 Apr 6:1-7. doi: 10.1007/s40726-021-00178-4.
11. Selim S, Akter N, Nayan SI, Chowdhury FI, Saffoon N, Khan F, Ahmed KS, Ahmed MI, Hossain MM, Alam MA. Flacourtia indica fruit extract modulated antioxidant gene expression, prevented oxidative stress and ameliorated kidney dysfunction in isoprenaline administered rats. Biochem Biophys Rep. 2021 May 18;26:101012. \\doi: 10.1016/j.bbrep.2021.101012.
12. Nayan SI, Chowdhury FI, Akter N, Rahman MM, Selim S, Saffoon N, Khan F, Subhan N, Hossain M, Ahmed KS, Hossain H, Haque MA, Alam MA. Leaf powder supplementation of Senna alexandrina ameliorates oxidative stress, inflammation, and hepatic steatosis in high-fat diet-fed obese rats. PLoS One. 2021 Apr 20;16(4):e0250261. doi: 10.1371/journal.pone.0250261.
13. Akter S, Banu TA, Goswami B, Osman E, Uzzaman MS, Habib MA, Jahan I, Mahmud ASM, Sarker MMH, Hossain MS, Shamsuzzaman AKM, Nafisa T, Molla MMA, Yeasmin M, Ghosh AK, Al Din SMS, Ray UC, Sajib SA, Hossain M, Khan MS. Coding-Complete Genome Sequences of Three SARS-CoV-2 Strains from Bangladesh. Microbiol Resour Announc. 2020 Sep 24;9(39):e00764-20. doi: 10.1128/MRA.00764-20.
14. Hossain, M., Bhattacharjee, A., Tabassum, T., Rahman, A., Islam, M. (2021). Prevalence and population biology of mastitis-causing Streptococcus uberis using an MLST based approach. Journal of Advanced Biotechnology and Experimental Therapeutics.
15. Bhattacharya P, Kumar M, Islam MT, Haque R, Chakraborty S, Ahmad A, Niazi NK, Cetecioglu Z, Nilsson D, Ijumulana J, van der Voorn T, Jakariya M, Hossain M, Ahmed F, Rahman M, Akter N, Johnston D, Ahmed KM. Prevalence of SARS-CoV-2 in Communities Through Wastewater Surveillance-a Potential Approach for Estimation of Disease Burden. Curr Pollut Rep. 2021 Apr 6:1-7. doi: 10.1007/s40726-021-00178-4.
16. Nayan SI, Chowdhury FI, Akter N, Rahman MM, Selim S, Saffoon N, Khan F, Subhan N, Hossain M, Ahmed KS, Hossain H, Haque MA, Alam MA. Leaf powder supplementation of Senna alexandrina ameliorates oxidative stress, inflammation, and hepatic steatosis in high-fat diet-fed obese rats. PLoS One. 2021 Apr 20;16(4):e0250261. doi: 10.1371/journal.pone.0250261.
17. Kuddus, S.A., Bhuiyan, M.I., Hossain M., Subhan, N. et al. Antioxidant-rich Tamarindus indica L. leaf extract reduced high-fat diet-induced obesity in rat through modulation of gene expression. Clin Phytosci 6, 68 (2020). https://doi.org/10.1186/s40816-020-00213-9
18. Dutta S, Khatun A, Gupta DR, Surovy MZ, Rahman MM, Mahmud NU, Emes RD, Warry A, West HM, Clarke ML, Hoque MN, Hossain MM, Salam MA, Islam MT. Whole-Genome Sequence of a Plant Growth-Promoting Strain, Serratia marcescens BTL07, Isolated from the Rhizoplane of Capsicum annuum L. Microbiol Resour Announc. 2020 Apr 30;9(18):e01484-19. doi: 10.1128/MRA.01484-19.
19. Hossain M, Tasnim S, Safa A, Rayhan ABH, Khan MTIA, Bulbul N, Sadique A, Ahsan GU, Jime JS. Draft Genome Sequence of Bacillus cereus TN10, a Chromium-Resistant and -Reducing Strain Isolated from Tannery Effluent. Microbiol Resour Announc. 2020 Jul 2;9(27):e00603-20.
20. Tamanna Afroze, Aura Rahman, Mrinmoy Sarkar , Abdus Sadique , Jahidul Alam , Sohel Rahman, Maqsud Hossain. Analysis of RNA-Seq Data of 10000 Samples of Single-cell Transcriptome, 2019 International Conference on Mechatronics, Robotics and Systems Engineering (MoRSE), Bali, Indonesia, 2019, pp. 259-264, \\doi: 10.1109/MoRSE48060.2019.8998690.
21. A. S. M. Zisanur Rahman, Arittra Bhattacharjee, Abdullah All Jaber, Maqsud Hossain, Kazi Nadim Hasan, Sohidul Islam and Zaied Ahmed Bhuyan* (2020) “High-Risk Non-synonymous SNPs of Human Bcl-2 Gene Alters Structural Stability and Small Molecule Binding”, Bioresearch Communications-(BRC). Dhaka, Bangladesh, 6(1), pp. 791-800.
22. Chowdhury, S.M.Z.H., Nazir, K.H.M.N.H., Hasan, S. et al. Whole genome analysis of Black Bengal goat from Savar Goat Farm, Bangladesh. BMC Res Notes 12, 687 (2019). https://doi.org/10.1186/s13104-019-4700-7
23. Jain M, Islam S, Rahman ASMZ, Akhtar S, Hasan KN, Ahsan GU, Khaleque A,
Hossain M. Molecular analysis of hemagglutinin, neuraminidase, matrix genes
provide insight into the genetic diversity of seasonal H3N2 human influenza a
viruses in Bangladesh during July-August, 2012. Virusdisease. 2018
Mar;29(1):54-60. doi: 10.1007/s13337-018-0431-y. Epub 2018 Feb 1. PubMed PMID:
29607359; PubMed Central PMCID: PMC5877854.
24. Hossain M, Alam M, Khaleque A, Islam S, Sadique A, Khan N, Halim Z, Sarker M,
El-Sayed NM, Huq A, Ahsan GU, Colwell RR. Virulence-Related Genes Identified from
the Genome Sequence of the Non-O1/Non-O139 \textit{Vibrio cholerae} Strain VcN1, Isolated
from Dhaka, Bangladesh. Genome Announc. 2018 Mar 8;6(10). pii: e01513-17.\\doi:
10.1128/genomeA.01513-17. PubMed PMID: 29519847; PubMed Central PMCID:
PMC5843720.
25. Hossain MS, Akhter MZ, Hossain MM, Shishir MA, Khan SN, Hoq MM. Complete
Genome Sequence of \textit{Bacillus subtilis} Strain MH1, Which Has a High Level of
Bacteriocin-Like Activity, Isolated from Soil in Bangladesh. Genome Announc. 2018
Jun 21;6(25). pii: e00516-18. doi: 10.1128/genomeA.00516-18. PubMed PMID:
29930040; PubMed Central PMCID: PMC6013613.
26. Hossain M, Egan SA, Coffey T, Ward PN, Wilson R, Leigh JA, Emes RD. Virulence
related sequences; insights provided by comparative genomics of Streptococcus
uberis of differing virulence. BMC Genomics. 2015 Apr 23;16:334. doi:
10.1186/s12864-015-1512-6. PubMed PMID: 25898893; PubMed Central PMCID:
PMC4427978.
27. Regan CS, Yon L, Hossain M, Elsheikha HM. Prevalence of Entamoeba species in
captive primates in zoological gardens in the UK. PeerJ. 2014 Jul 29;2:e492. doi:
10.7717/peerj.492. eCollection 2014. PubMed PMID: 25097822; PubMed Central PMCID:
PMC4121542.
28. Ahmed MU, Chawdhury FA, Hossain M, Sultan SZ, Alam M, Salahuddin G, Alam A,
Nessa K, Nahar S, Shama-A-Waris, Alam A, Rahman M. Monitoring antimicrobial
susceptibility of Neisseria gonorrhoeae isolated from Bangladesh during
1997-2006: emergence and pattern of drug-resistant isolates. J Health Popul Nutr.
2010 Oct;28(5):443-9. PubMed PMID: 20941895; PubMed Central PMCID: PMC2963766.
29. Saha SK, Darmstadt GL, Baqui AH, Crook DW, Islam MN, Islam M, Hossain M, El
Arifeen S, Santosham M, Black RE. Molecular basis of resistance displayed by
highly ciprofloxacin-resistant Salmonella enterica serovar Typhi in Bangladesh. J
Clin Microbiol. 2006 Oct;44(10):3811-3. PubMed PMID: 17021117; PubMed Central
PMCID: PMC1594770.
30. Nessa K, Waris SA, Sultan Z, Monira S, Hossain M, Nahar S, Rahman H, Alam M,
Baatsen P, Rahman M. Epidemiology and etiology of sexually transmitted infection
among hotel-based sex workers in Dhaka, Bangladesh. J Clin Microbiol. 2004
eb;42(2):618-21. PubMed PMID: 14766825; PubMed Central PMCID: PMC344477.
31. Hossain M, Uddin A, Malek A, Bashar SAM, Noor P, Rahman M. Production of Extracellular Xylanase from Intestinal Bacteria in Termite. Bangladesh Journal of Microbiology. 2008 Dec; 25(2); 123-127
32. Hossain M, A. A. T., Bashar SAM, Nayeem S, Shafiq, Gomes D J, Shams F 2009. Shams An overview on Tuberculosis - Causative agent, Epidemiology, Management and Vaccination Bangladesh Journal of Medical Sciences, 15, 1-8.
33. Hossain M, F. S., Bashar SAM, Khaleque A, Azam K, Choudhury Rafiqul Ahsan, and Donald James 2009. Clinical aspects of Helicobacter pylori infection. Bangladesh Journal of Medical Sciences, 14, 155-168.
PhD in Bioinformatics, University of Nottingham, 2011 – 2015.
MSc Bioinformatics , University of Abertay Dundee, 2002-2004
MSc Microbiology, 1st Class, University of Dhaka, Bangladesh, 2000
BSc Microbiology, 1st Class Honours, University of Dhaka, Bangladesh 1998.
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Bioinformatics, Biostatistics, Microbiology, Clinical and Diagnostic Microbiology
Pathogen Genomics, Bioinformatics, Comparative Genomics, Evolutionary Biology, Systems Biology