Center of Excellence in Higher Education
The First Private University in Bangladesh

Dr. Muktadir Shahid Hossain

Full Time Faculty
Associate Professor

Ph.D. in Pharmaceutical Biology, University of Tokyo, Japan

Phone: +880-2-55668200 Ext: 1919
Email: muktadir.hossain01@northsouth.edu
Office:

Curriculum Vitae
 
 
 

 

 
 

Muktadir Shahid Hossain is an Associate Professor of the Department of Biochemistry and Microbiology of NSU. He joined the department in Janauary 2017. 

Muktadir S. Hossain completed his Ph.D. at the University of Tokyo, Japan in 2004 where he showed that quiescent (G0) phase cells of multicellular eukaryotes like mammals and insects require DNA topoisomeras II enzyme for the re-entry into the cell cycle, whereas the unicellular eukaryotes like yeast do not. The title of his Ph.D. dissertation is "Requirement for DNA topoisomerase II during the G0-to-S phase transition in mammalian and insect cells". In the University of Tokyo as a Ph.D. student, he participated in the isolation of temperature-sensitive mutants of the pathogenic bacterium, Staphylococcus aureus. In the University of Tokyo as a Ph.D. student, he also showed that the DNA double-strand break-inducing drugs that are used to treat cancner can induce myogenic differentiation in cultured cells of the fruit fly, Drosophila melanogaster. In the University of Tokyo as a Research Assistant, he established the larvae of the silk moth, Bombyx mori as animal model to study purified toxins from pathogenic bacteria like S. aureus and Pseudomonas aeruginosa by injection. He joined the National Cancer Institute (NCI) of National Institutes of Health (NIH) in Bethesda, Maryland, USA as a post-doctoral fellow where he identified certain transcription factors that regulate initiation of embryonic muscle differentiation in D. melanogaster. Then, he joined the Shanghai Institutes of Biological Sciences, China as a Senior Research Fellow to show that the evolutionarily conserved transcription factor, FoxO is required for the activation of ecdysone signaling during starvation for better survival of larvae of both B. mori and D. melanogaster. In Andong National University, South Korea, he showed as a Visiting Fellow along with other researchers that the ICA69 gene is a cytosolic phospholipase A2 that participates in the immunity of the beet armyworm, Spodoptera exigua, an important pest insect. As a Research Professor in Chonbuk National University, South Korea, he introduced the CRISPR-Cas9 gene-editing technique in the pest insect-killing fungus, Beauveria bassiana which is useful not only to identify the molecular mechanism of pathogenicity of B. bassiana towards insect pests by gene knock-out but also to improve the pathogenicity of the fungus by overexpressing virulence genes. Since B. bassiana is harmless to humans but can kill pest insects efficiently, it can be used in the context of Bangladesh where the use of chemical pesticides is widespread to control insect pests to increase crop production in an environmentally friendly way. He is also trying to identify novel anticancer drugs from biological extracts by using silkworm larvae as a cancer model via knocking out tumor-suppressor genes using the CRISPR-Cas9 technology. 

List of Publications as an NSU employee: 

1. Inteshar AA, Hossain MM, Uddin MA, Bari ML, Hossain MS (2020) Therapeutic effect of antibiotics against Escherichia coli O157:H7 in silk moth larvae animal model. Curr Microbiol 77(9):2172-2180. 

List of Conference Presentations as an NSU employee:

1. Invited speaker in the "4th International Caparica Conference in Antibiotic Resistance 2021" (13th-17th June, Caparica, Portugal) which was held online due to the ongoing COVID-19 pandemic. Title of the talk: "Therapeutic effect of antibiotics against Escherichia coli O157:H7 in silk moth larvae animal model". (Abstract page: 94)

Previous Publications:

  1. Hossain MS, Uddin MA, Gomosta AR, Hossain MA (2000) Effect of ethylene on some submergence-tolerant and susceptible rice (Oryza sativa) varieties of Bangladesh. Bangladesh J Biochem 6:1-17.
  2. Hossain MS, Akimitsu N, Takaki T, Hirai H, Sekimizu K (2002) ICRF-193, a catalytic inhibitor of DNA topoisomerase II, inhibits re-entry into the cell division cycle from quiescent state in mammalian cells. Genes Cells 7(3):285-294.
  3. Kaito C, Kurokawa K, Hossain MS, Akimitsu N, Sekimizu K (2002) Isolation and characterization of temperature-sensitive mutants of the Staphylococcus aureus dnaC FEMS Microbiol Lett 210(1):157-164.
  4. Akimitsu N, Adachi N, Hirai H, Hossain MS, Hamamoto H, Kobayashi M, Aratani Y, Koyama H, Sekimizu K (2003) Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase IIα. Genes Cells 8(4):393-402.
  5. Hossain MS, Akimitsu N, Kurokawa K, Sekimizu K (2003) Myogenic differentiation of Drosophila Schneider cells by DNA double-strand break-inducing drugs. Differentiation 71(4-5):271-280.
  6. Hossain MS, Kurokawa K, Akimitsu N, Sekimizu K (2004) DNA topoisomerase II is required for the G0-to-S phase transition in Drosophila Schneider cells, but not in yeast. Genes Cells 9(10):905-917.
  7. Hossain MS, Kurokawa K, Sekimizu K (2005) Induction of fusion-competent myoblast-specific gene expression during myogenic differentiation of Drosophila Schneider cells by DNA double-strand breaks or replication inhibition. Biochim Biophys Acta 1743(1-2):176-186.
  8. Hossain MS, Hamamoto H, Matsumoto Y, Razanajatovo IM, Larranaga J, Kaito C, Kasuga H, Sekimizu K (2006) Use of silkworm larvae to study pathogenic bacterial toxins. J Biochem 143(3):439-444.
  9. Hossain MS, Liu Y, Zhou S, Li K, Tian L, Li S (2013) 20-Hydroxyecdysone-induced transcriptional activity of FoxO upregulates brummer and acid lipase-1 and promotes lipolysis in Bombyx fat body. Insect Biochem Mol Biol 43(9):829-838.
  10. Li K, Guo E, Hossain MS, Li Q, Cao Y, Tian L, Deng X, Li S. (2015) Bombyx E75 isoforms display stage- and tissue-specific responses to 20-hydroxyecdysone. Sci Rep 5:12114.
  11. Lee SJ, Kim S, Kim JC, Lee MR, Hossain MS, Shin TS, Kim TH, Kim JS (2017) Entomopathogenic Beauveria bassiana granules to control soil-dwelling stage of western flower thrips, Frankliniella occidentalis (Thysanoptera:Thripidae). Biocontrol 62:639-648.
  12. Lee SJ, Yang YT, Kim S, Lee MR, Kim JC, Park SE, Hossain MS, Shin TY, Nai YS, Kim JS. (2019) Transcriptional response of bean bug (Riptortus pedestris) upon infection with entomopathogenic fungus, Beauveria bassiana JEF-007. Pest Manag Sci 75(2):333-345.

 

  1. Pre-doctoral and doctoral course scholarships (Monbusho) from the Ministry of Education, Sports, and Culture of the Government of Japan.
  2. Fogarty Cancer Research Training Award (CRTA) as a Visiting Fellow from the National Cancer Institute, National Institutes of Health, USA.

Degree

Year

Institute

Subject

Grade/Class/ Division

Ph.D.

2004

University of Tokyo, Japan

Pharmaceutical Biology

Grade A

M.Sc.

 

2000

 

University of Dhaka, Bangladesh

Biochemistry & Molecular Biology

First Class First

B.Sc.

1998

University of Dhaka, Bangladesh

Biochemistry & Molecular Biology

First Class First

Higher Secondary Certificate

1993

Notre Dame College,

Dhaka, Bangladesh

Science

First Division with STAR

 

Secondary School Certificate

1991

Motijheel Govt. Boys’ High School, Dhaka, Bangladesh

Science

First Division with STAR

2016 (June-December): Research Professor in the lab of Prof. Jae-Su Kim of the Department of Agricultural Biology, Chonbuk National University, Jeonju, South Korea.

2016 (January-April): Visiting Fellow in the lab of Prof. Yonggyun Kim of the Department of Bioresource Sciences, Andong National University, Andong, South Korea.

2011-2015: Senior Research Fellow in the lab of Prof. Sheng Li of Key Laboratory of Insect Developmental and Evolutionary Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

2005-2008: Fogarty Cancer Research Fellow in the lab of Dr. Bruce M. Paterson, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

2004-2005: Research Assistant in the lab of Prof. Kazuhisa Sekimizu, Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.

2001-2004: Doctoral course student in the lab of Prof. Kazuhisa Sekimizu, Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.

2000-2001: Pre-doctoral course student in the lab of Prof. Kazuhisa Sekimizu, Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.

2000: Research Assistant in the lab of Prof. M. Anwar Hossain, Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh.

 

BIO201 (Introduction to Biochemistry & Biotechnology)

CHE202/BBT202 (Bio-organic Chemistry)

BBT312/BBT204 (Molecular Biology)

Dr. Hossain in interested in using silkworm larvae as an animal model to study pathogenicity of bacteria isolated in Bangladesh. He is interested to isolate novel antibiotics that will be useful against multidrug-resistant bacteria using silkworm-bacteria infection model. Dr. Hossain is interested in isolating entomopathogenic (insect-killing) organisms like fungi, nematode, bacteria as environmentally-friendly biocontrol agents to control pest insects like mosquitoes, fall armyworm etc. Dr. Hossain is interested in using the CRISPR-Cas9 technology for gene-targeting in silkworm larvae to induce cancerous growth to identify biological extracts that exhibit anticancer effects. Dr. Hossain also studies the role of hormonal signaling in response to starvation in insects and mammals.