BOOK, BOOK CHAPTER

2012

1. Ashraful Alam, Shaikh Jamal Uddin, Lindsay Brown (2012) Mitogen-activated protein kinase and natural phenolic compounds in cardiovascular remodeling, Studies in Natural Product Chemistry 38:159-190. (e-Book chapter). doi: 10.1016/B978-0-444-59530-0.00006-X. I designed the idea of this review and drafted the review for submission as First author.

 REVIEW Articles in Peer Review Journals

2021

1. Md. Ashraful Alam, Priota Islam, Nusrat Subhan, Md. Mizanur Rahman, Ferdous Khan, Geoffrey E. Burrows, Lutfun Nahar and Satyajit Dey Sarker (2021) Potential Health Benefits of Anthocyanins in Oxidative Stress Related Disorders, Phytochemistry Review. (accepted)
2. Nahar, L., Uddin, S. J., Alam, M. A. and Sarker, S. D. (2021) Extraction of naturally occurring cannabinoids: An update, Phytochemical Analysis, 2021; 32:228–241.

 2019

3. Ashraful Alam (2019) Anti-hypertensive effect of cereal antioxidant ferulic acid and its mechanism of action, Frontiers in Nutrition, section Nutritional Immunology, 6:121.
4. Mominul Islam, Rokeya Nazneen Jarna, Preeti Jain, Md. Ashraful Alam, Hasan Mahmud Reza, Murad Hossain, Sourabh Paul, S. M. Rayan Kabir, Dr. Md. Majedur Rahamn (2019). Potential antidiabetic medicinal plants in Bangladesh, A comprehensive review. Word Journal of Pharmaceutical Research. 8(6): 140-150.

List of Publications of Research Articles

2021

1. Pintu Miah, Surovi Binte Sharmin Mohona, Md. Mizanur Rahman, Nusrat Subhan, Ferdous Khan, Hemayet Hossain, Shazid Md. Sharker and Md. Ashraful Alam (2021) Supplementation of Cumin Seed Powder Prevents Oxidative Stress, Hyperlipidemia and Non-Alcoholic Fatty Liver in High Fat Diet fed Rats. Biomedicine and Pharmacotherapy (accepted on 7th July 2021). I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
2. Saima Selim, Noushin Akter, Shariful Islam Nayan,  Faizul Islam Chowdhury,  Nadia Saffoon, Ferdous Khan, Khondoker Shahin Ahmed, Md Iqbal Ahmed, Mohammad Maqsud Hossain, Md Ashraful Alam (2021) Flacourtia indica fruit extract modulated antioxidant gene expression, prevented oxidative stress and ameliorated kidney dysfunction in isoprenaline administered rats. Biochemistry and Biophysics Reports, 26 (2021) 101012. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
3. Md. Raihan Uzzaman Prince, S. M. Neamul Kabir Zihad, Puja Ghosh, Nazifa Sifat, Razina Rouf, Gazi Mohammad Al Shajib, Md. Ashraful Alam, Jamil A. Shilpi, Shaikh J. Uddin (2021) Amaranthus spinosus attenuated obesity induced metabolic disorders in high- carbohydrate-high-fat diet fed obese rats, Frontiers in Nutrition (Accepted)
4. Shariful Islam Nayan1, Faizul Islam Chowdhury, Noushin Akter, Md Mizanur Rahman, Saima Selim, Nadia Saffoon, Ferdous Khan, Nusrat Subhan, Maqsud Hossain, K. Shahin Ahmed, Md. Hemayet Hossain, Md. Areeful Haque, Md Ashraful Alam (2021) Leaf powder supplementation of Senna alexandrina ameliorates oxidative stress, inflammation, and hepatic steatosis in high-fat diet-fed obese rats, Plos One (Accepted). I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
5. Shahnaz Siddiqua, Faiza Hamid Jyoti, Nadia Saffoon, Pintu Miah, Soumen Lasker,
   Hemayet Hossain, Raushanara Akter, Md. Iqbal Ahmed, Md Ashraful Alam (2021) Ethanolic extract of Coccinia grandis prevented glucose intolerance,  hyperlipidemia and oxidative stress in high fat diet fed rats. Phytomedicine Plus 1:100046. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
6. Md. Mizanur Rahman, Nusaira Beenta Shahab, Pintu Miah, Md Mahamudur Rahaman, Arafat Ulla Kabir, Nusrat Subhan, Ahad Ali Khan, Mirola Afroze,  Mala Khan, K. Shahin Ahmed, Hemayet Hossain, Md. Areeful Haque, Md Ashraful Alam (2021) Polyphenol-rich leaf of Aphanamixis polystachya averts liver inflammation, fibrogenesis and oxidative stress in ovariectomized Long-Evans rats. Biomedicine and Pharmacotherapy, 24;138:111530. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.

2020

1. Fariha Kabir, Kamrun Nahar, Md. Mizanur Rahman, Fariha Mamun, Shoumen Lasker, Ferdous Khan, Tahmina Yasmin, Khondker Ayesha Akter, Nusrat Subhan and Md. Ashraful Alam (2021) Etoricoxib treatment  prevented body weight gain and ameliorated oxidative stress in liver of high-fat diet fed rats. Naunyn-Schmiedeberg's Archives of Pharmacology, 394:33–47 doi: 10.1007/s00210-020-01960-9. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
2. Nitol Debnath, Farzana Binte Rafique, Nasrin Akhter, Anayt Ulla, Tahmina Yesmin, Md Nurul Islam, Md Ashraful Alam (2021) Supplementation of Psidium guajava Leaves Powder Prevents Hepatotoxicity and Inflammation in Carbon Tetrachloride (CClâ‚„) Administered Rats. Current Bioactive Compounds, DOI : 10.2174/1573407216999200715162928. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
3. Noushin Akter, Faizul Islam Chowdhury, Saima Selim, Shariful Islam Nayan, Ferdous Khan, Nusrat Subhan, Hemayet Hossain, Md Mizanur Rahman, Md. Areeful Haque,  Md Ashraful Alam (2020) Polyphenolics in ramontchi protect cardiac tissues via suppressing isoprenaline-induced oxidative stress and inflammatory responses in Long-Evans rats, Journal of Functional Foods, 75: 104250.
4. Syed Abdul Kuddus, Mazharul Islam Bhuiyan, Nusrat Subhan, Md. Hasanuzzaman Shohag, Aura Rahman, Muhammad Maqsud Hossain, Md. Ashraful Alam, Ferdous Khan (2020) Antioxidant-rich Tamarindus indica L. leaf extract reduced high-fat diet-induced obesity in rat through modulation of gene expression, Clinical Phytoscience, 6:68.
5. Syed A. Kuddus, Zarin Tasnim, Md. Hasanuzzaman Shohag, Tahmina Yasmin, Md. Sahab Uddin, Muhammad M. Hossain, Nusrat Subhan, Md. Ashraful Alam, Ferdous Khan (2020) Dillenia indica fruit extract suppressed diet-induced obesity in rat by down-regulating the mRNA level of proadipogenic transcription factors and lipid metabolizing enzymes. Current Nutrition & Food Science, DOI : 10.2174/1573401316999200901173319.
6. Raquibul Hasan, Shoumen Lasker, Ahasanul Hasan, Farzana Zerin, Mushfera Zamila, Faisal Parvez, Md. Mizanur Rahman, Ferdous Khan, Nusrat Subhan and Md. Ashraful Alam (2020). Canagliflozin ameliorates renal oxidative stress and inflammation by stimulating AMPK-Akt-eNOS pathway in the isoprenaline-induced oxidative stress model. Scientific Reports, 10, 14659, doi.org/10.1038/s41598-020-71599-2.
7. Raquibul Hasan, Shoumen Lasker, Ahasanul Hasan, Farzana Zerin, Mushfera Zamila, Faizul Islam Chowdhury, Shariful Islam Nayan, Md. Mizanur Rahman, Ferdous Khan, Nusrat Subhan, Md Ashraful Alam (2020) Canagliflozin attenuates isoprenaline-induced cardiac oxidative stress by stimulating multiple antioxidant and anti-inflammatory signaling pathways. Scientific Reports, 10, 14459, doi.org/10.1038/s41598-020-71449-1.
8. Nazifa Sifat, S. M. Neamul Kabir Zihad, Farhana Lovely, Razina Rouf, Gazi Mohammad Al Shajib, Md. Ashraful Alam, Jamil A. Shilpi, Shaikh J. Uddin (2020) Supplementation of Heliotropium indicum Linn attenuates obesity and associated metabolic disorders in high carbohydrate high fat diet induced obese rats. Food Biochemistry, https://doi.org/10.1111/jfbc.13444 (Accepted).
9. Md Mizanur Rahman, Khandoker Usran Ferdous, Shraboni Roy, Iffat Ara Nitul, Fariha Mamun, Md Hemayet Hossain, Nusrat Subhan,  Md Ashraful Alam, Md. Areeful Haque, (2020) Polyphenolic compounds of Amla prevents oxidative stress and fibrosis in the kidney and heart of 2K1C rats.  Food Science & Nutrition 8(7): 3578–3589. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
10. Salma Khan, Md. Mizanur Rahman, Fariha Kabir, Kamrun Nahar, Fariha Mamun, Shoumen Lasker, Nusrat Subhan, Md. Hemayet Hossain, Lutfun Nahar, Satyajit D. Sarker,  Md. Ashraful Alam, Md. Areeful Haque (2020) Trichosanthes dioica Roxb. prevents hepatic inflammation and fibrosis in CCl4-induced ovariectomized rats, Clinical Nutrition Experimental, 33: 1-17. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
11. Nitol Debnath, Farzana Binte Rafique, Nasrin Akhter, Anayt Ulla, Tahmina Yasmin, Md Nurul Islam, Md Ashraful Alam (2020) Supplementation of Psidium guajava leaves powder prevents hepatotoxicity and inflammation in carbon tetrachloride (CClâ‚„) administered rats. Current Bioactive Compounds DOI : 10.2174/1573407216999200715162928 (accepted). I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
12. Emranul Haque Masum, Hashim Mushtasin Reza, Mohammad Jobaer, Razia Sultana, Md Rafin Hossain, Shamim Hossen, Md Ashraful Alam and MN Islam (2020) Anti-inflammatory, and Anti-nociceptive Properties of Leaf & Root Extracts of Amaranthus spinosus (2020) EC Pharmacology and Toxicology 8.6: 44-51.
13. Fariha Mamun, Mushfera Zamila, Md. Mizanur Rahman, Nusrat Subhan, Hemayet Hossain, S. M. Raquibul Hasan, Md. Ashraful Alam, Md. Areeful Haque (2020) Polyphenolic compounds of litchi leaf augment kidney and heart functions in 2K1C rats, Journal of Functional Food 64: 103662.   I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
14. Biswajit Sikder, Farzana Akter, Anayt Ulla, Nusrat Subhan, Md. Iqbal Ahmed, Md Ashraful Alam (2020) HMG-CoA Reductase Inhibitor, Rosuvastatin, Averted Oxidative Stress, Inflammation and Fibrosis in Liver of Carbon Tetrachloride-Induced Rats, Journal of Advanced Biotechnology and Experimental Therapeutics 3(1): 01-08. . I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.

2019

1. Shoumen Lasker, Md Mizanur Rahman, Faisal Parvez, Mushfera Zamila, Pintu Miah, Kamrun Nahar; Fariha Kabir, Surovi Binte Sharmin, Nusrat Subhan, Gias U. Ahsan*, and Md Ashraful Alam* (2019) High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation, Scientific Reports 9, Article number: 20026 (2019). I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
2. Farzana Akther Sumi, Biswajit Sikder, Md Mizanur Rahman, Shamshad Rahman Lubna, Anayt Ulla, Md Hemayet Hossain, Ismet Ara Jahan, Md Ashraful Alam,  and Nusrat Subhan (2019) Phenolic content analysis in Aloe vera gel and evaluation of the effect of aloe gel supplementation on oxidative stress and fibrosis in isoproterenol-administered cardiac damage in rats, Preventive Nutrition and Food Science, 24(3): 254-264. . I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
3. Nasrin Akhter; Md. Ashraful Alam; Md. Anower Hussain Mian; Hasan Mahmud Reza; Md. Saiful Islam  (2019) YABA (Methamphetamine tablet) Administration altered cellular antioxidant status and developed fibrosis in liver of rats. Pharmacology Online, 2:269-281.
4. Kousik Ahmed Khan, Manik Zahan, Fatema Zohura Talukder, Riaz Uddin,
   Manik Chandra Shill, Hemayet Hossain, Lutfun Nahar, Satyajit Dey Sarker,
   Md. Ashraful Alam and Hasan Mahmud Reza (2019) Alternanthera bicolor Produces Hypoglycemic Effect in Alloxan-Induced Diabetic Mice through its Antioxidant Activity, Dhaka Univ. J. Pharm. Sci. 18(1): 49-60.
5. Preeti Jain, Arifa Haque, Tairin Islam, Md. Ashraful Alam and Hasan Mahmud Reza (2019) Comparative evaluation of Ziziphus mauritiana leaf extracts for phenolic content, antioxidant and antibacterial activities. Journal of Herbs, Spices and Medicinal Plants, 25:3, 236-258.  DOI: 10.1080/10496475.2019.1600627.
6. Md. Irfan Amin Chowdury, Md. Mamun Al-Amin, ARM Saifullah, Mohammed Nazmul Alam, Preeti Jain, Murad Hossain, Md. Ashraful Alam, Mohsin Kazi, Ajaz Ahmad, Mohamamd Raish, Abdulmohsen Alqahtani, Hasan Mahmud Reza (2019) Levocarnitine improves AlCl₃-induced spatial working memory impairment in Swiss albino mice, Frontiers in Neuroscience, 13.278.
7. Fariha Kabir, Kamrun Nahar, Md Mizanur Rahman, Md. Abdullah Al Mamun, Md. Faruk, Hasan Mahmud Reza, Hemayet Hossain, Nusrat Subhan, Md Ashraful Alam (2019) Beetroot powder supplementation prevents oxidative stress and inflammatory cells infiltration in isoprenaline-induced myocardial damage in rats. Mediterranean Journal of Nutrition and Metabolism, 12(2):197-209. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
8. Md. Abdullah Al Mamun, Md. Faruk, Md. Mizanur Rahman, Kamrun Nahar, Fariha Kabir, Md Ashraful Alam and Nusrat Subhan (2019) High carbohydrate high fat diet induced hepatic steatosis and dyslipidemia were ameliorated by Psidium guajava leaf powder supplementation in rats. Evidenced Based Complementary and Alternative Medicine. Article ID 1897237.
9. ^¥Anayt Ulla, ^¥Md Ashraful Alam, Mosfiqur Rahman, D M Isha Olive Khan, Biswajit Sikder, Monirul Islam, Tarikur Rahman, Nilima Rahman, Hasan Mahmud Reza, Preeti Jain, Nusrat Subhan (2018) Supplementation of Citrus maxima Fruits Peel Powder Improves Glucose Intolerance and Prevents Oxidative Stress in Liver of Alloxan-Induced Diabetic Rats. Mediterranean Journal of Nutrition and Metabolism, 12 (1): 33-44, DOI: 10.3233/MNM-18211. ^¥Contributed equally. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.

1. Research Excellence award 2021, From North South University, Bangladesh, for outstanding research performance.
2. North South University internal research grant award 2020-2021 for “Evaluation of xanthin oxidase inhibitor febuxostat on kidney dysfunction in 2K1C rats” as a Principal investigator.
3. NST special allocation grants 2019-2020 for “Isolation of bio-active
   compounds from Senna alexandrina and evaluation of the antiobesity and antihyperlipidemic activity in high fat diet fed rats”, As Principal Investigator.
4. North South University internal research grant award 2019-2020 for “Evaluation of Cratava nurvala extract in kidney dysfunction of 2K1C rats” as a Principal investigator.
5. North South University internal research grant award 2018-1019 for “Effect of Apocynin on Oxidative Stress, Fibrosis, and Myocardial Damage in Isoproterenol Induced Rats” as a Principal investigator.
6. Ministry of Science and Technology, Bangladesh R & D project research grant 2017-1018 “Effect of superoxide dismutase mimetic temple on carbon tetra chloride induced hepatic inflammation and fibrosis in rats” as a Principal investigator.
7. North South University internal research grant award 2016-1017 for “Effect of antioxidant rich functional foods on oxidative stress, inflammation and cardiovascular remodeling in animal model” as a Principal investigator.
8. Ministry of Science and Technology, Bangladesh R & D project research grant 2016-1017 “Effect of L-arginine of oxidative stress inflammation and fibrosis in heart of fludrocortisone induced cardiac remodeling in rats” as a Principal investigator.
9. Best Poster Presenter Awards (as a team leader) from 4^th AYUNS international Conference 2016.
10. Ministry of Science and Technology, Bangladesh R & D project research grant 2015-1016 for “উচ্চমাত্রার ফ্যাট ও কার্বোহাইড্রেট  à¦¯à§à¦•à§à¦¤ খাবার খাওয়ার ফলে মোটা হয়ে যাওয়া ইঁদুরের উপর কার্ডামম (এলাচি) পাওডারের প্রভাব সংক্রান্ত গবেষণা ” as a Principal Investigator.
11. Ministry of Science and Technology, Bangladesh special allocation grant 2015-2016 for “Evaluating the role of natural antioxidants in diet induced obesity and fat metabolizing gene expression in animal model” as a Co-Investigator.
12. Dean’s Award 2016 from School of Health and Life Sciences, North South University, Bangladesh for outstanding research performance.
13. Travel Awards for Joint Annual Scientific Meeting of the Nutrition Society of New Zealand and the Nutrition Society of Australia 2011.
14. Islamic Development Bank Three Years Merit PhD Scholarship-2009-2012.
15. University of Queensland International Research Tuition Awards 2009-2012.
16. University Scholarship at Graduate Level (MS in Pharmacology) from Bangladesh Agricultural University Bangladesh 2005-2006.
17. Grants for thesis preparation from Bangladesh Agricultural University, Bangladesh, 2006.

Academic Career

1. Chairman, Department of Pharmaceutical Sciences North-South University Bangladesh (04-07-2018 to 31-01-2019).
2. Associate Professor, Department of Pharmaceutical Sciences, North-South University Bangladesh (01-04-2018 to till date).
3. Assistant Professor, Department of Pharmaceutical Sciences, North-South University Bangladesh (24-05-2014 to 01-04-2018).
4. Assistant Professor (Part Time), Department of Pharmaceutical Sciences, North-South University Bangladesh (02-08-2013 to 23-05-2014).
5. Casual academic staff, School of Biomedical Sciences, The University of Queensland 2009, 2012, 2013.
6. Lecturer, Department of Pharmacy, Faculty of Science, Stamford University Bangladesh. 02-05-2013 to 05-02-2009; February, 2009 to June, 2013 (on Study Leave)

RESEARCH WORK DONE IN UDERGRADUATE AND POST GRADUATE LEVEL

1)             “Role of natural antioxidants and phenolic compounds in cardiometabolic syndrome” for the fulfillment of the degree PhD (Biomedical Science), The University of Queensland. Supervised by Professor Lindsay Brown, Department of Biological and Physical Sciences, University of Southern Queensland, Australia.

2)             “Protein binding nature of the antihypertensive drugs (atenolol and amlodipine) and drug- drug interaction in presence of arsenic” for the partial fulfillment of the degree MS in Pharmacology from Bangladesh Agricultural University. Supervised by Professor Dr. Md Abdul Awal, Department of Pharmacology, Bangladesh Agricultural University, Mymensingh.

3)             “Pharmacological investigation of the crude extract of the plant Xylocarpus granatum” for the Partial fulfillment of the degree Bachelor of Pharmacy (Hons.) from Khulna University, Bangladesh. Supervised by Assoc. Professor Mokaddez Sarder, Pharmacy Discipline, Khulna University.

Expertise:

1. Langendorff heart preparation and Ischemic conditioning.
2. Organ bath for thoracic aorta and rat ileum.
3. Non-invasive tail-cuff blood pressure measurement in rat.
4. Animal model studied- diet induced obese rat model, L-NAME induced hypertensive rat model, DOCA-salt induced hypertensive rat model, spontaneously hypertensive rat model, neuropathic pain model, aortic banding for cardiac hypertrophy.
5. Histological process- tissue processing, sectioning, slide preparation and staining for heart, liver, kidney and pancreas. Normal architecture and special staining for fibrosis and inflammatory cells, insulin positive area and islets size etc.
6. Antioxidant enzyme assay for SOD and catalase, Gpx, fluorescence assay for ROS etc.
7. Western blot for eNOS, heme oxygenase, MAPKs etc.
8. Mitochondrial isolation, respiration, proton leak and membrane potential assay.
9. Laser scanning confocal microscopy, fluorescence microscopy etc.
10. In-vitro antioxidant assays for natural compound.
11. Cell culture, MTT assay, functional TNF-alpha production assay.
12. Statistics software, Prism, SPSS.

None

Currently teaching
Undergraduate level
Pharmacology I; Organic Pharmacy II; Pharmaceutical Microbiology I and Pharmacognosy
Graduate Level
Toxicology and Safety Pharmacology

PROFESSIONAL MEMBERSHIP

1. Graduate Pharmacist Association, Bangladesh
2. Canadian Society of Basic and Clinical Pharmacology
3. Bangladesh Society for Basic Experimental Pharmacology and Therapeutics.
4. Nutrition society Australia, 2010-2011
5. Australian Society for Medical Research, 2010-2011

REVIEW REQUEST PERFORMED FOR

1. BMC Complementary and Alternative Medicine
2. Journal of Dietary Supplements
3. Karger Pharmacology
4. African Journal of Complementary and Alternative Medicine.
5. Iranian Journal of Pharmacology and Therapeutics.
6. Oriental Pharmacy and Experimental Medicine.
7. Journal of Herbs Spices and Medicinal Plants.
8. Medicinal Chemistry Communications, Royal Society of Chemistry Journal.
9. Associate editor- Stamford Journal of Pharmaceutical Sciences, 2009.

My lab (under my leadership) is currently doing research on several projects.
1. CCl₄ induced cirrhotic liver in rats.
2. 2K1C Goldblatt hypertensive rat model.
3. ISO induced cardiac remodeling in rats.
4. High fat diet induced obesity in rats and natural compounds.
we are currently using Red amaranth (Lal shak), Rice bran, Guava leaves as well as ramipril, sitagliptin, etorocoxib as therapeutic intervention for inflammation and oxidative stress on those experimental model.

Figure: ISO induced cardiac remodeling in rat heart.




Figure: CCl₄ induced liver fibrosis and inflammation in rats.