Center of Excellence in Higher Education
The First Private University in Bangladesh

Dr. Chaman Ara Keya

Full Time Faculty
 Professor

Ph.D., in Advanced Bioscience, Ochanomizu University, Japan

Phone: +880-2-55668200 Ext: 1917
Email:  chaman.keya@northsouth.edu
Office: SAC808

Curriculum Vitae
 

Dr. Chaman Ara Keya is a professor of the department of Biochemistry and Microbiology at North South University, Dhaka.She has been working at NSU since 2015. She has more than 10 years of teaching and student supervision experience at undergraduate and graduate levels. Dr. Keya's skills in the field of Biochemistry & Biotechnology help students develop biological reasoning of life, prepare themselves for working in the industry and academia, and grow curiosity.  During her thirteen-year carrier from 2000 to 2013 as a researcher at advanced Institute of Science and technology (AIST), Chiba University (Tokyo) and Japan’s largest comprehensive research institution  RIKEN (The Institute of Physical and Chemical Research) she has focused on acquiring knowledge in a diverse range of scientific disciplines.

Dr. Keya's research fields include the genetic basis of communicable and non-communicable diseases, computational genomics for human Therapeutics, and sustainable technology in clinical diagnostic services to measure and monitor health status against prevalent infectious diseases, vector-borne diseases as well as non-communicable diseases. Previously my research focus was to develop qualitative and quantitative aspects of traits of plant cultivars to support food biotechnology. She has been publishing articles in peer-reviewed journals such as Nature Genetics, Scientific Reports, Frontiers in Plant Science, PLOS ONE, etc.

    1. Anika Bushra Lamisa# 1 2, Ishtiaque Ahammad # 2, Arittra Bhattacharjee # 2, Mohammad Uzzal Hossain 2, Ahmed Ishtiaque 1, Zeshan Mahmud Chowdhury 2, Keshob Chandra Das 3, Md Salimullah 3, Chaman Ara Keya 4  A meta-analysis of bulk RNA-seq datasets identifies potential biomarkers and repurposable therapeutics against Alzheimer's disease. Sci Rep. 2025 Feb 11;15(1):5135. doi: 10.1038/s41598-025-87907-7.

     

    1. Ishtiaque Ahammad a,1 , Tabassum Binte Jamal a,1 , Anika Bushra Lamisa a,1 , Arittra Bhattacharjee a , Nayeematul Zinan b , Md. Zahid Hasan Chowdhury b , Shah Mohammad Naimul Islam b , Kazi Md. Omar Faruque c , Zeshan Mahmud Chowdhury a , Mohammad Uzzal Hossain a , Keshob Chandra Das d , Chaman Ara Keya e , Md Salimullah d*. Subtractive genomics study of Xanthomonas oryzae pv. Oryzae reveals repurposable drug candidate for the treatment of bacterial leaf blight in rice. Journal of Genetic Engineering and Biotechnology, January 2024. https://doi.org/10.1016/j.jgeb.2024.100353 (Q2)

     

    1. Ishtiaque Ahammad a,1 , Anika Bushra Lamisa a,b,1 , Sadia Sharmin c,1 , Arittra Bhattacharjee a , Zeshan Mahmud Chowdhury a , Tanvir Ahamed c , Mohammad Uzzal Hossain a , Keshob Chandra Das d , Md Salimullah d , Chaman Ara Keya b*. Subtractive genomics study for the identification of therapeutic targets against Cronobacter sakazakii: A threat to infants. Heliyon, April 2024. https://doi.org/10.1016/j.heliyon.2024.e30332 (Q1)

     

    1. Ishtiaque Ahammad 1,‡, Anika Bushra Lamisa1,‡, Arittra Bhattacharjee 1,‡, Tabassum Binte Jamal1, Md. Shamsul Arefin2, Zeshan Mahmud Chowdhury1, Mohammad Uzzal Hossain 1, Keshob Chandra Das3, Chaman Ara Keya2, Md. Salimullah3. AITeQ: a machine learning framework for Alzheimer’s prediction using a distinctive five-gene signature. Briefings in Bioinformatics, June 2024. https://doi.org/10.1093/bib/bbae291 (Q1)

     

    1. Ishtiaque Ahammad1,5, Arittra Bhattacharjee1,5, Zeshan Mahmud Chowdhury1,5, Anisur Rahman 1,5, Mohammad Uzzal Hossain1,5, Gourab Dewan2 , Shiny Talukder2 , Keshob Chandra Das3 , Chaman Ara Keya4 & Md Salimullah. Gut microbiome composition reveals the distinctiveness between the Bengali people and the Indigenous ethnicities in Bangladesh. Communications Biology, April 2024. https://doi.org/10.1038/s42003-024-06191-9. (Q1)
    2. Zeshan Mahmud Chowdhury a,1 , Tabassum Binte Jamal a,1 , Ishtiaque Ahammad a , Arittra Bhattacharjee a , Anika Bushra Lamisa a , Jannatul Maoa Jani b , Md Fahim Israk b , Mohammad Uzzal Hossain a , Keshob Chandra Das c , Chaman Ara Keya d , Md Salimullah c,* Identification of repurposable drug targets in Mycoplasma pneumoniae using subtractive genomics, molecular docking and dynamics simulation. Heliyon, November 2023. https://doi.org/10.1016/j.heliyon.2023.e21466. (Q1)

     

    1. Sumon Kumar Das, Afzal Sheikh*, Nikhat Ara, Suma Mita Biswas, Abhinandan Chowdhury, Fatimah Az Zahra, Chaman Ara Keya* Evaluation of Disk Potentiation Test (DPT) and Double Disk Synergy Test (DDST) for the Detection of Metallo-β-Lactamases (MBLs) in Clinical Isolates of Bangladesh. Advances in Infectious Diseases, 2023, 13, 609-626. Doi: https://doi.org/10.4236/aid.2023.134050

     

    1. Ishtiaque Ahammad a , Zeshan Mahmud Chowdhury a , Arittra Bhattacharjee a , Sheikh Sunzid Ahmed b , Farzana Akter b , Mohammad Uzzal Hossain a , Keshob Chandra Das c , Chaman Ara Keya d , Md. Salimullah c,* Structure-based pharmacological screening, molecular docking and dynamic simulation reveals Dexketoprofen as a repurposable drug against Alzheimer’s disease. Informatics in Medicine Unlocked, October 2023. https://doi.org/10.1016/j.imu.2023.101380 (Q2)

     

    1. Ahammad I, Jamal TB, Bhattacharjee A, Chowdhury ZM, Rahman S, Hassan MR, Hossain MU, Das KC, Keya CA, Salimullah M. Impact of highly deleterious non-synonymous polymorphisms on GRIN2A protein's structure and function. PLoS One2023 Jun 15;18(6):e0286917. doi: 10.1371/journal.pone.0286917  (Q1)
    2. Al-Mamun A, Ahammad I, Ahmed SS, Akter F, Hossain SI, Chowdhury ZM, Bhattacharjee A, Das KC, Keya CA, Salimullah M. Pharmacoinformatics and molecular dynamics simulation approach to identify anti-diarrheal potentials of Centella asiatica(L.) Urb. against Vibrio cholerae J Biomol Struct Dyn 2023 Mar 16;1-14 doi: 10.1080/07391102.2023.2191736  (Q2)

     

    1. Bhattacharjee A, Pranto SMAM, Ahammad I, Chowdhury ZM, Juliana FM, Das KC, Keya CA, Salimullah M. High risk genetic variants of human insulin receptor substrate 1(IRS1) infer structural instability and functional interference. J Biomol Struct Dyn

    2023 Mar 12;1-15 doi: 10.1080/07391102.2023.2187232  (Q2)

     

    1. Hossain MU, Ferdous N, Reza MN, Ahammad I, Tiernan Z, Wang Y, O'Hanlon F, Wu Z, Sarker S, Mohiuddin AKM, Das KC, Keya CA, Salimullah M. Pathogen-driven gene expression patterns lead to a novel approach to the identification of common therapeutic targets. Sci Rep 2022 Dec 6;12(1):21070. doi: 10.1038/s41598-022-25102-8 (Q1)

     

    1. Zeshan Mahmud ChowdhuryID1 , Arittra Bhattacharjee1 , Ishtiaque Ahammad1 , Mohammad Uzzal Hossain1 , Abdullah All JaberID2 , Anisur RahmanID1 , Preonath Chondrow Dev1 , Md. SalimullahID3 , Chaman Ara Keya2 *(2022) Exploration of Streptococcus core genome to reveal druggable targets and novel therapeutics against S. pneumonia. PLOS ONE. https://doi.org/10.1371/journal.pone.0272945 (Q1)

     

    1. Arittra Bhattacharjee1, Ishtiaque Ahammad1, Zeshan Mahmud Chowdhury1· Keshob Chandra Das2, Chaman Ara Keya3,Salimullah2 (2022).Proteome‑Based Investigation Identified Potential Drug Repurposable Small Molecules Against Monkeypox Disease. Molecular Biotechnology. https://doi.org/10.1007/s12033-022-00595-w  (Q3)

     

    1. Farhana Haque, Ishrat Jabeen, Chaman Ara Keya and Sabbir R. Shuvo * (2022) Whole-genome sequencing and comparative analysis of heavy metals tolerant Bacillus anthracis FHq strain isolated from tannery effluents in Bangladesh. AIMS Microbiology, 8 (2): 227–239. DOI: 10.3934/microbiol.2022018 (Q2)

     

    1. Hadisur Rahman a, Muhammad Shamsuzzaman a,b, Irfan Ahmed a, Md. Moniruzzaman a, U.S. Mahzabin Amin a, Mohammad Uzzal Hossain c, Keshob Chandra Das a, Chaman Ara Keya b, Md. Salimullah a,* (2022). Association of metallothionein 1A gene polymorphism rs8052394 with type 2 diabetes mellitus in Bangladeshi population. Human Gene. https://doi.org/10.1016/j.humgen.2022.201098  (Q4)

     

    1. Mohammad Uzzal Hossain a,b,1, Ishtiaque Ahammad b,1, Arittra Bhattacharjee b, Zeshan Mahmud Chowdhury b, Anisur Rahman b, Tahia Anan Rahman c, Taimur Md Omar d, Mohammad Kamrul Hasan e, Md Nazrul Islam f, Md Tabassum Hossain Emon d, Keshob Chandra Das c, Chaman Ara Keya g, Md Salimullah (2022). Protein-protein interactions network model underlines a link between hormonal and neurological disorders. Informatics in Medicine Unlocked. https://doi.org/10.1016/j.imu.2022.100866 (Q2)

     

    1. MuslimaKhatuna1BhabeshBorphukanb1IftekharAlamaChamaAraKeyacHaseenaKhandMalireddy K.ReddybSalimullahe An improved Agrobacterium mediated transformation and regeneration protocol for successful genetic engineering and genome editing in eggplant. Sceintia Horticulturae, Feb. 2022 https://doi.org/10.1016/j.scienta.2021.110716 (Q1)

     

    1. Khatun M, Borphukan B, Alam I, Keya CA, Panditi V, Khan H, Huq S, Reddy MK, Salimullah. Mitochondria-Targeted SmsHSP24.1 Overexpression Stimulates Early Seedling Vigor and Stress Tolerance by Multi-Pathway Transcriptome-Reprogramming. Front Plant Sci. 2021 Nov 23;12:741898. doi: 10.3389/fpls.2021.741898 (Q1)

     

    1. Abdullah All Jaber1 , Zeshan Mahmud Chowdhury1,2, Arittra Bhattacharjee1,2, Muntahi Mourin3 , Chaman Ara Keya1 , Zaied Ahmed Bhuyan1 * Microsecond molecular dynamics simulations revealed the inhibitory potency of amiloride analogs against SARS-CoV-2 E viroporin. Genomics & Informatics, November 2021 (Q3)

     

    1. Mohammad Uzzal Hossain, ab Ishtiaque Ahammad, b Arittra Bhattacharjee,b Zeshan Mahmud Chowdhury,b Md. Tabassum Hossain Emon,d Keshob Chandra Das,e Chaman Ara Keyac and Md. Salimullah*e. Whole genome sequencing for revealing the point mutations of SARS-CoV-2 genome in Bangladeshi isolates and their structural effects on viral proteins. RSC Adv., 2021, November DOI: 10.1039/d1ra05327b (Q1)

     

    1. Wave-wise comparative genomic study for revealing the complete scenario and dynamic nature of COVID-19 pandemic in Bangladesh. Ahammad I, Hossain MU, Rahman A, Chowdhury ZM, Bhattacharjee A, Das KC, Keya CA, Salimullah M .PLoS One. 2021 Sep 29;16(9):e0258019. doi: 10.1371/journal.pone.0258019. eCollection 2021. (Q1)

     

    1. Atikur Rahman1 · Tasmina Ferdous Susmi1 · Farzana Yasmin1 Arittra Bhattacharjee2,3 Mohammad Uzzal Hossain2 Keshob Chandra Das, Chaman Ara Keya, Md Salimullah Unveiling ancestral relations, host–pathogen interactions and comparative viral miRNA insights of dengue virus serotypes; Network Modeling Analysis in Health Informatics and Bioinformatics, 2021

     

    1. Keshob Chandra Das4 · Chaman Ara Keya3 Md. Salimullah4Arittra Bhattacharjee, Mohammad Uzzal Hossain, Zeshan Mahmud Chowdhury, S. M. Adiat Rahman, Zaied Ahmed Bhuyan, Md. Salimullah & Chaman Ara Keya; Insight of druggable cannabinoids against estrogen receptor β in breast cancer ; Journal of Biomolecular Structure and Dynamics, 1-10; IF: 3.310; Citation: 5; Scopus Indexed

     

     

    1. Mohammad Uzzal Hossain a,1, Arittra Bhattacharjee a,b,1, Md. Tabassum Hossain Emon c,1, Zeshan Mahmud Chowdhury b,1, Md. Golam Mosaib d, Muntahi Mourin b,f, Keshob Chandra Das e, Chaman Ara Keya b, Md. Salimullah Recognition of plausible therapeutic agents to combat COVID-19: An omics data based combined approach, Gene, 145368; Available online 17, December 2020; IF: 2.984

     

    1. Coding-Complete Genome Sequence of SARS-CoV-2 Isolate from Bangladesh by Sanger Sequencing. Moniruzzaman M, Hossain MU, Islam MN, Rahman MH, Ahmed I, Rahman TA, Bhattacharjee A, Amin MR, Rashed A, Keya CA, Das KC, Salimullah M.Microbiol Resour Announc. 2020 Jul 9;9(28):e00626-20. doi: 10.1128/MRA.00626-20.
    2. Novel mutations in NSP-1 and PLPro of SARS-CoV-2 NIB-1 genome mount for effective therapeutics. Hossain MU, Bhattacharjee A, Emon MTH, Chowdhury ZM, Ahammad I, Mosaib MG, Moniruzzaman M, Rahman MH, Islam MN, Ahmed I, Amin MR, Rashed A, Das KC, Keya CA, Salimullah M.J Genet Eng Biotechnol. 2021 Apr 2;19(1):52. doi: 10.1186/s43141-021-00152-z.

     

    1. Microsecond molecular dynamics simulations revealed the inhibitory potency of amiloride analogs against SARS-CoV-2 E viroporin. Jaber AA, Chowdhury ZM, Bhattacharjee A, Mourin M, Keya CA, Bhuyan ZA.Genomics Inform. 2021 Dec;19(4):e48. doi: 10.5808/gi.21040. Epub 2021 Dec 31.

     

    1. Wave-wise comparative genomic study for revealing the complete scenario and dynamic nature of COVID-19 pandemic in Bangladesh. Ahammad I, Hossain MU, Rahman A, Chowdhury ZM, Bhattacharjee A, Das KC, Keya CA, Salimullah M.PLoS One. 2021 Sep 29;16(9):e0258019. doi: 10.1371/journal.pone.0258019. eCollection 2021.

     

    1. Whole genome sequencing for revealing the point mutations of SARS-CoV-2 genome in Bangladeshi isolates and their structural effects on viral proteins. Hossain MU, Ahammad I, Bhattacharjee A, Chowdhury ZM, Hossain Emon MT, Chandra Das K, Keya CA, Salimullah M.RSC Adv. 2021 Dec 3;11(61):38868-38879. doi: 10.1039/d1ra05327b. eCollection 2021 Nov 29.

     

    1. Mohammad Uzzal Hossain, Taimur Md Omar, Iftekhar Alam, Keshob Chandra Das, AKM Mohiuddin, Chaman Ara Keya, Md Salimullah Pathway based therapeutic targets identification and development of an interactive database CampyNIBase of Campylobacter jejuni RM1221 through non-redundant protein dataset. PloS one, 13(6), p.e0198170, 2018. Available at: http://www.ncbi.nlm.nih.gov/pubmed/29883471.

     

    1. Hossain, M.U., Keya, C.A., et al., 2018. An Immunopharmacoinformatics Approach in Development of Vaccine and Drug Candidates for West Nile Virus. Frontiers in chemistry, 6, p.246. Available at: http://www.ncbi.nlm.nih.gov/pubmed/30035107

     

    1. Mahbubul Hasan SM, Abhinandan Chowdhury and Chaman Ara Keya*Urease: The Ultimate Therapeutic Target for HelicobacterPylori. Int J cell Sci&molboil. Volume 3 Issue 5 - February 2018, DOI: 19080/IJCSMB.2018.03.555625

     

    1. Mohammad Uzzal Hossain1, Keshob Chandra Das2, U.S. Mahzabin Amin2, Chaman Ara Keya3 and Md. Salimullah2*. Sorting Out Non-Synonymous Single Nucleotide Polymorphism Leads to Novel Biomarker Discovery for Disease Prognosis. Curr Trends Biomedical Eng & Biosci Volume 3 Issue 2 - April 2017 , DOI: 19080/CTBEB.2016.01.555608

     

    1. Mohammad Uzzal Hossain1, Arif Khan2, Abu Hashem3, Md. Monirul Islam1, Mohammad Neaz Morshed2, Chaman Ara Keya4 and Md. Salimullah5*. Finding Potential Therapeutic Targets against Shigella flexneri through Proteome Exploration. Front. Microbiol., 22 November 2016. Vol. 7, article 1817. doi: 10.3389/fmicb.2016.01817

     

    1. Tasnuva Akhtar1, M. Rowfur Rahman1, Sumita Biswas1, Rasheda Perveen2, M. Shah Alam1, Farida Adib Khanum2, M. Amirul Islam3, Shahangir Biswas4, Chaman Ara Keya5, M. Manirujjaman2. Identification of Microbial Contamination of Popular Fruits of Bangladesh and Assessment the Effects of Alternative Preservatives Instead of Formalin. American Journal of Microbiological Research. 4, No. 5, 2016, pp 138-142.  doi: 10.12691/ajmr-4-5-2

     

    1. A. Khaleque, C.A. Keya, K.N. Hasan, M.M. Hoque, Y. Inatsud, M.L. Barib. Use of cloves and cinnamon essential oil to inactivate Listeria monocytogenes in ground beef at freezing and refrigeration temperatures. LWT - Food Science and Technology 2016

     

    1. Mohammad Uzzal Hossain, Abu Hashem, Chaman Ara Keya, Md. Salimullah. Therapeutics insight with inclusive immunopharmacology explication of Human Rotavirus A for the treatment of Diarrhea. Frontiers in Pharmacology, 2016

     

    1. Mohammad Uzzal Hossain, Md. Arif Khan, S. M. Rakib-Uz-Zaman, Mohammad Tuhin Ali, Md. Saidul Islam, Chaman Ara Keya, and Md. Salimullah.Treating Diabetes Mellitus: Pharmacophore Based Designing of Potential Drugs from Gymnema sylvestre against Insulin Receptor Protein. BioMed Research International Volume 2016, Article ID 3187647, 14 pages

     

    1. Mohammad Uzzal Hossain, Abu Zaffar Shibly, Taimur Md. Omar, Fatama Tous Zohora, Umme Sara Santona, Md. Jakir Hossain, md. Sadek Hosen Khoka, Chaman Ara Keya, Md. Salimullah. Towards finding the linkage between metabolic and age -related disorders using semantic gene data network analysis. Bioinformation 12(1): 22-26 (2016)

     

    1. Fort A, Hashimoto K, Yamada D, Salimullah M, Keya CA, Saxena A, Bonetti A, Voineagu I, Bertin N, Kratz A, Noro Y, Wong CH, de Hoon M, Andersson R, Sandelin A, Suzuki H, Wei CL, Koseki H; FANTOM Consortium, Hasegawa Y, Forrest AR, Carninci P. Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance. Nature Genet. 2014; 46(6):558-66. doi: 10.1038/ng.2965.

     

    1. Li, S. Ogita, C.A. Keya, H. Ashihara. Expression of Caffeine Biosynthesis Genes in Tea (Camellia sinensis). Z. Naturforsch. 2008; 63(3-4):267-70.

     

    1. A. Keya, A. Crozier and H. Ashihara. Inhibition of caffeine biosynthesis in tea (Camellia sinensis) and coffee (Coffea arabica) plants by ribavirin. FEBS Lett. 2003; 554(3):473-7.

     

    1. A. Keya, Z. I. Seraj and S. Mahmood. RFLP analysis of salt-tolerant rice varieties. Dhaka Univ. J. Biol. Sci. 1999; 8(2):17-24.
  1. Awarded Japan Government Scholarship (Monbukagakusho) to carry out PhD research in Ochanomizu University, Tokyo, Japan.
  1. Received University Grant Scholarship (University of Dhaka) for brilliant performance in B.Sc. (Hons.) examination
  2. Obtained Higher Secondary Board Scholarship for brilliant performance in Higher Secondary School Certificate examination.

Education:

Ph.D. in Advanced Bioscience
 University of Ochanomizu, Tokyo, Japan
Year of completion 2005
M.Sc in Biochemistry and Molecular Biology
 University of Dhaka
Year of completion 1997
B.Sc (Honors) in Biochemistry and Molecular Biology
University University of Dhaka
Year of completion 1995

Research and Teaching Experiences

  • Professor, Department of Biochemistry & Microbiology, North South University, Dhaka, Bangladesh from November, 2023 to till now
  • Associate Professor, Department of Biochemistry & Microbiology, North South University, Dhaka, Bangladesh from April 2018 to October 2023
  • Assistant Professor, Department of Biochemistry & Microbiology, North South University, Dhaka, Bangladesh from January 2015 to March 2018
  • Senior Lecturer, Gono University, Bangladesh from January 2014 to December 2014.
  • Technical Staff I, Functional Genomics Technology Team, Omics Science Centre, RIKEN Yokohama Institute, Japan from June 2011 to June 2013
  • Researcher, Chuo University, Tokyo, Japan from May 2008 to August 2009
  • Postdoctoral Research Fellow, Ochanomizu University, Tokyo, Japan from October 2007 to April 2008
  • Postdoctoral Research Fellow, Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan from April 2005 to September 2006
  • Scientific Officer in Biotechnology Division, International Food, and Radiation Biology (IFRB), Atomic Energy Commission, Savar, Dhaka, Bangladesh from January 2000 to October 2000
  • Lecturer, Department of Biochemistry, Tejgaon College, Dhaka, Bangladesh from June 1998 to December 1999

Used to teach

Biology, Molecular Biology, Plant Biochemistry & Biotechnology, Molecular Biotechnology, Nutritional Biochemistry, Pharmaceutical Biotechnology, Metabolism & Genes, and diseases

  • Member, Japanese Society of Laboratory Medicine, Japan
  • Member, Graduate Biochemists Association, Bangladesh
  • Member, Bangladesh Society for Biochemistry and Molecular   Biology, Bangladesh

Research Interest

My research fields include the genetic basis of communicable and non-communicable diseases, computational genomics for human Therapeutics, and sustainable technology in clinical diagnostic services to measure and monitor health status against prevalent infectious diseases, vector-borne diseases as well as non-communicable diseases. Previously my research focus was to develop qualitative and quantitative aspects of traits of plant cultivars to support food biotechnology.

My research sheds light on i) genomic evolution of the pathogen related to specific infectious diseases, identification of predominant variants, and host-pathogen interaction thus uncovering novel targets for drug development. ii) genetic etiology of non-communicable diseases such as hypothyroidism, and neurological disorders which further help us to categorize the risk of the disease and to develop a genetic screening protocol as well as drug repurposing iii) the production of transgenic plants such as abiotic stress tolerance eggplants, decaffeinated green tea etc. to enhance the resilience to food security