Full Time Faculty Professor B.Pharm (Hons.), MS in Pharmacology, PhD (UQ, Australia) Phone: +880-2-55668200 Ext: 1963 Curriculum Vitae |
I am Dr Md Ashraful Alam, currently serving as a Professor at Department of Pharmaceutical Sciences, North South University Bangladesh. I obtained B.Pharm (Hons.) from Pharmacy Discipline, Khulna University in 2004. I also completed MS In Pharmacology from Bangladesh Agricultural University, Mymensingh in June, 2006. I was awarded PhD degree from The University of Queensland, Australia on May, 2013. My PhD research work focused on the understanding of the causes of obesity and related cardiovascular complications. To understand this process, we used diet induced obese rat model. We measured the development of vascular dysfunction and cardiac remodeling along with other parameters of metabolic syndrome. We also used pure natural antioxidant to evaluate their preventive nature against obesity development and efficacy in our obese rat model and tried to understand the mechanism of action in molecular level. A good number of articles have been published from my research work at UQ.
Now, we have several animal models for studying oxidative stress and related organ dysfunctions. We are also trying to find out the cures for these oxidative stress related complications from natural sources.
BOOK, BOOK CHAPTER
2012
REVIEW Articles in Peer Review Journals
2021
2019
List of Publications of Research Articles
2025
2024
6. Ishrat Jahan, SM Hasan Hafiz, Mirza Alimullah, Asif Ul Haque, Md. Fakruddin, Nusrat Subhan, Ferdous Khan, Khondoker Shahin Ahmed, Kazi Akramuddaula, Hemayet Hossain, Md Ashraful Alam (2024) Evaluation of fenugreek (Trigonella foenum-graecum L.) powder supplementation on metabolic syndrome, oxidative stress and inflammation in high-fat diet fed rats. Pharmacological Research-Natural Products, 5:100116.
7. Mirza Alimullah, A S M Nafiur Rahman, Puspa Sornaker, Kazi Akramuddaula, Sumaia Sarif, Shahnaz Siddiqua, Kaniz Fatima Mitu, Ishrat Jahan, Ferdous Khan, Nusrat Subhan, Md. Ashraful Alam (2024) Evaluation of Terminalia arjuna bark powder supplementation on isoprenaline-induced oxidative stress and inflammation in the heart of Long Evans rats, understanding the molecular mechanism of this old medicinal plant. Journal of Medicinal Natural Products, 1(1), 100004. I designed the idea of this research, trained the students to execute the research, analyzed the data, and drafted the manuscript for submission as corresponding author.
8. Md. Mizanur Rahman; Mirza Alimullah, Tahmina Yasmin, Nasrin Akhter, Iqbal Ahmed, Ferdous Khan; Mousumi Saha, Mohammad A. Halim, Nusrat Subhan, Md. Areeful Haque, Md Ashraful Alam (2024) Cardioprotective action of apocynin in isoproterenol induced cardiac damage is mediated through Nrf-2/HO-1 signaling pathway, Food Science & Nutrition, 12:9108–9122. I designed the idea of this research, trained the students to execute the research, analyzed the data, and drafted the manuscript for submission as the corresponding author.
9. Shamima Sultana, Sadia Afrin Eva, Shahnaz Siddiqua, Hridoy Chandra Ghosh, Md Sakil Amin, Sadia Rahman, Nusrat Subhan, Md Ashraful Alam, Md Nurul Islam, (2024) Black seed (Nigella sativa) powder supplementation prevented oxidative stress and cardiac fibrosis in isoprenaline administered rats. J. Bio. Exp. Pharmacol. 2024, 2, 31-45. https://doi.org/10.62624/JBEP0009
10. Mirza Alimullah, Asif Ul Haque Shuvo, Md. Delower Hossain, Khondoker Shahin Ahmed, Hemayet Hossain, Abdullah Al Rakib, Kazi Akramuddaula, Md. Ashraful Alam, Nusrat Subhan (2024) Evaluation of bioactive compounds from various citrus fruits in Bangladesh and evaluation of their effect as antioxidant and on glucose metabolizing enzymes in vitro. J. Bio. Sci. Exp. Pharmacol. 2024, 2, 46-64. https://doi.org/10.62624/JBEP00010
11. Mirza Alimullah, Indrajit Barua Muthsuddy, Iftakhar Alam, Aka Barua Joya, Tahasin Akhter, Asma Akter, Md Sakil Amin, Sraboni Anmol Khan, Md Ashraful Alam, Nusrat Subhan (2024) Evaluation of Mimosa pudica leaf extract on oxidative stress and fibrosis in liver of carbon tetrachloride (CCl4) administered rats, J. Bio. Exp. Pharmacol. 2024, 2, 65-77. https://doi.org/10.62624/JBEP00011
12. Mirza Alimullah, Asif Ul Haque Shuvo, Ishrat Jahan, Iffat Nowshin Ismail, S.M. Mufidul Islam, Mahnaj Sultana, Mahmudur Rahman Saad, Md. Sabbir Raihan, Ferdous Khan, Md. Ashraful Alam, Nusrat Subhan (2024) Evaluation of the modulating effect of epidermal growth factor receptor inhibitor cetuximab in carbon-tetrachloride induce hepatic fibrosis in rats, Biochemistry and Biophysics Reports, 21:38:101689.
13. Tammana Tabassum Eysha Chisty, Sumaia Sarif, Ishrat Jahan, Iffat Nowshin Ismail, Faizul Islam Chowdhury, Shahnaz Siddiqua, Tahmina Yasmin, Md Nurul Islam, Ferdous Khan, Nusrat Subhan, Md. Ashraful Alam, (2024) Protective effects of l-carnitine on isoprenaline -induced heart and kidney dysfunctions: modulation of inflammation and oxidative stress-related gene expression in rats. Heliyon, 10 (3), e25057. I designed the idea of this research, trained the students to execute the research, analyzed the data, and drafted the manuscript for submission as the corresponding author.
14. Fariha Kabir, Kamrun Nahar, Samia Hussain, Tahmina Yasmin, Nasrin Akhter, M. Nurul Islam, Md Mizanur Rahman, Hemayet Hossain, Md. Areeful Haque, Md Ashraful Alam, Nusrat Subhan (2024) Pomegranate fruit peel extract improves cardiac functions via suppressing oxidative stress, fibrosis, and myocardial infarction in Long-Evans rats. J. Adv. Biotechnol. Exp. Ther. 7(1): 190-204. I designed the idea of this research, trained the students to execute the research, analyzed the data, and drafted the manuscript for submission as the corresponding author.
2023
15. Mirza Alimullah, Nishad Anjum, Md Junaeid Rahman, Khondoker Shahin Ahmed, Hemayet Hossain, Md Ashraful Alam, Nusrat Subhan (2023) Identification of polyphenols and evaluation of antioxidant and α-amylase inhibitory activity of wheat bran extracts, Journal of Biosciences and Experimental Pharmacology 2023, 1, 91-114.
16. Ishrat Jahan, Proma Saha, Tammana Tabassum Eysha Chisty, Kaniz Fatima Mitu, Faizul Islam Chowdhury, Khondoker Shahin Ahmed, Hemayet Hossain, Ferdous Khan, Nusrat Subhan, Md. Ashraful Alam, Crataeva nurvala bark (Capparidaceae) extract modulates oxidative stress related genes expression, restored antioxidant enzymes and prevents oxidative stress in the kidney and heart of 2K1C rats, Evidence Based Complementary and Alternative Medicine, Volume 2023, Article ID 4720727. https://doi.org/10.1155/2023/4720727. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
17. Ishrat Jahan, Md. Didarul Islam, Sumaia Sarif, Israt Jahan Amena, Asif Ul Haque Shuvo, Noushin Akter, Faizul Islam Chowdhury, Raushanara Akter, Iqbal Ahmed, Ferdous Khan, Nusrat Subhan, and Md. Ashraful Alam, Tempol alters antioxidant enzyme function, modulates multiple genes expression, and ameliorates hepatic and renal impairment in carbon tetrachloride (CCl4) intoxicated rats. Livers (MDPI) 2023, 3(1), 105-120. I designed the idea of this research, trained the students to execute the research, analyzed the data, and drafted the manuscript for submission as the corresponding author.
2022
18. Faizul Islam Chowdhury, Tahmina Yasmin, Raushanara Akter, Md Nurul Islam, Mohammed Maksud Hossain, Ferdous Khan, Adil Aldhahrani, Mohamed Mohamed Soliman, Nusrat Subhan, Md. Areeful Haque, Md Ashraful Alam (2022) Resveratrol treatment modulates several antioxidant and anti-inflammatory genes expression and ameliorated oxidative stress-mediated fibrosis in the kidneys of high-fat diet-fed rats, Saudi Pharmaceutical Journal, 30 (10) 1454-1463. I designed the idea of this research, trained the students to execute the research, analyzed the data, and drafted the manuscript for submission as the corresponding author.
19. Ahasanul Hasan, Farzana Zerin, Sreelakshmi Menon, Md Ashraful Alam, Raquibul Hasan (2022) Mechanism of canagliflozin-induced vasodilation in resistance mesenteric arteries and the regulation of systemic blood pressure, Journal of Pharmacological Sciences, 150(4):211-222.
20. Ajay K Panday, Farzan Zerin, Sreelaskshmi N Menon, Khue P. Nguyen, Tran Vo, Morgan L Daniel, Sherif Hafez, Md Ashraful Alam, Raquibul Hasan (2022) Neflamapimod Induces Vasodilation in Resistance Mesenteric Arteries by Inhibiting p38 Mitogen-Activated Protein Kinase Alpha (MAPKα) and Heat-Shock Protein 27 (Hsp27) Phosphorylation. Scientific Reports, 12, Article number: 4905.
21. Shahnaz Siddiqua, Biswajit Sikder, Anayt Ulla, Farzana Akhter Sumi, Nasrin Akhter, Md Nurul Islam, Md Ashraful Alam, Ramipril, an angiotensin-converting enzyme inhibitor, ameliorates oxidative stress, inflammation, and hepatic fibrosis in alloxan-induced diabetic rats, J Adv Biotechnol Exp Ther. 2022; 5(3): 510-522. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
2021
22. Tahmina Yasmin, Md. Mizanur Rahman, Ferdous Khan, Fariha Kabir, Kamrun Nahar, Shoumen Lasker, Md. Didarul Islam, Mohammad Maqsud Hossain, Raquibul Hasan, Sohel Rana and Md Ashraful Alam (2021) High fat diet induced non-alcoholic fatty liver and dyslipidemia was ameliorated by metformin treatment, which also modulates antioxidant genes by Nrf-2-HO mediated pathway in rats, Biochemistry and Biophysics Reports, 28:101168. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
23. Pintu Miah, Surovi Binte Sharmin Mohona, Md. Mizanur Rahman, Nusrat Subhan, Ferdous Khan, Hemayet Hossain, Shazid Md. Sharker and Md. Ashraful Alam (2021) Supplementation of cumin seed powder prevents oxidative stress, hyperlipidemia and non-alcoholic fatty liver in high fat diet fed rats. Biomedicine and Pharmacotherapy 141: 111908. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
24. Saima Selim, Noushin Akter, Shariful Islam Nayan, Faizul Islam Chowdhury, Nadia Saffoon, Ferdous Khan, Khondoker Shahin Ahmed, Md Iqbal Ahmed, Mohammad Maqsud Hossain, Md Ashraful Alam (2021) Flacourtia indica fruit extract modulated antioxidant gene expression, prevented oxidative stress and ameliorated kidney dysfunction in isoprenaline administered rats. Biochemistry and Biophysics Reports, 26 (2021) 101012. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
25. Md. Raihan Uzzaman Prince, S. M. Neamul Kabir Zihad, Puja Ghosh, Nazifa Sifat, Razina Rouf, Gazi Mohammad Al Shajib, Md. Ashraful Alam, Jamil A. Shilpi, Shaikh J. Uddin (2021) Amaranthus spinosus attenuated obesity induced metabolic disorders in high- carbohydrate-high-fat diet fed obese rats, Frontiers in Nutrition, 8:653918.
26. Shariful Islam Nayan1, Faizul Islam Chowdhury, Noushin Akter, Md Mizanur Rahman, Saima Selim, Nadia Saffoon, Ferdous Khan, Nusrat Subhan, Maqsud Hossain, K. Shahin Ahmed, Md. Hemayet Hossain, Md. Areeful Haque, Md Ashraful Alam (2021) Leaf powder supplementation of Senna alexandrina ameliorates oxidative stress, inflammation, and hepatic steatosis in high-fat diet-fed obese rats, Plos One, 16(4): e0250261. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
27. Shahnaz Siddiqua, Faiza Hamid Jyoti, Nadia Saffoon, Pintu Miah, Soumen Lasker,
Hemayet Hossain, Raushanara Akter, Md. Iqbal Ahmed, Md Ashraful Alam (2021) Ethanolic extract of Coccinia grandis prevented glucose intolerance,
hyperlipidemia and oxidative stress in high fat diet fed rats. Phytomedicine Plus 1:100046. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
28. Md. Mizanur Rahman, Nusaira Beenta Shahab, Pintu Miah, Md Mahamudur Rahaman, Arafat Ulla Kabir, Nusrat Subhan, Ahad Ali Khan, Mirola Afroze, Mala Khan, K. Shahin Ahmed, Hemayet Hossain, Md. Areeful Haque, Md Ashraful Alam (2021) Polyphenol-rich leaf of Aphanamixis polystachya averts liver inflammation, fibrogenesis and oxidative stress in ovariectomized Long-Evans rats. Biomedicine and Pharmacotherapy, 24;138:111530. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
2020
29. Fariha Kabir, Kamrun Nahar, Md. Mizanur Rahman, Fariha Mamun, Shoumen Lasker, Ferdous Khan, Tahmina Yasmin, Khondker Ayesha Akter, Nusrat Subhan and Md. Ashraful Alam (2021) Etoricoxib treatment prevented body weight gain and ameliorated oxidative stress in liver of high-fat diet fed rats. Naunyn-Schmiedeberg's Archives of Pharmacology, 394:33–47 doi: 10.1007/s00210-020-01960-9. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
30. Nitol Debnath, Farzana Binte Rafique, Nasrin Akhter, Anayt Ulla, Tahmina Yesmin, Md Nurul Islam, Md Ashraful Alam (2021) Supplementation of Psidium guajava Leaves Powder Prevents Hepatotoxicity and Inflammation in Carbon Tetrachloride (CCl₄) Administered Rats. Current Bioactive Compounds, DOI : 10.2174/1573407216999200715162928. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
31. Noushin Akter, Faizul Islam Chowdhury, Saima Selim, Shariful Islam Nayan, Ferdous Khan, Nusrat Subhan, Hemayet Hossain, Md Mizanur Rahman, Md. Areeful Haque, Md Ashraful Alam (2020) Polyphenolics in ramontchi protect cardiac tissues via suppressing isoprenaline-induced oxidative stress and inflammatory responses in Long-Evans rats, Journal of Functional Foods, 75: 104250.
32. Syed Abdul Kuddus, Mazharul Islam Bhuiyan, Nusrat Subhan, Md. Hasanuzzaman Shohag, Aura Rahman, Muhammad Maqsud Hossain, Md. Ashraful Alam, Ferdous Khan (2020) Antioxidant-rich Tamarindus indica L. leaf extract reduced high-fat diet-induced obesity in rat through modulation of gene expression, Clinical Phytoscience, 6:68.
33. Syed A. Kuddus, Zarin Tasnim, Md. Hasanuzzaman Shohag, Tahmina Yasmin, Md. Sahab Uddin, Muhammad M. Hossain, Nusrat Subhan, Md. Ashraful Alam, Ferdous Khan (2020) Dillenia indica fruit extract suppressed diet-induced obesity in rat by down-regulating the mRNA level of proadipogenic transcription factors and lipid metabolizing enzymes. Current Nutrition & Food Science, DOI : 10.2174/1573401316999200901173319.
34. Raquibul Hasan, Shoumen Lasker, Ahasanul Hasan, Farzana Zerin, Mushfera Zamila, Faisal Parvez, Md. Mizanur Rahman, Ferdous Khan, Nusrat Subhan and Md. Ashraful Alam (2020). Canagliflozin ameliorates renal oxidative stress and inflammation by stimulating AMPK-Akt-eNOS pathway in the isoprenaline-induced oxidative stress model. Scientific Reports, 10, 14659, doi.org/10.1038/s41598-020-71599-2.
35. Raquibul Hasan, Shoumen Lasker, Ahasanul Hasan, Farzana Zerin, Mushfera Zamila, Faizul Islam Chowdhury, Shariful Islam Nayan, Md. Mizanur Rahman, Ferdous Khan, Nusrat Subhan, Md Ashraful Alam (2020) Canagliflozin attenuates isoprenaline-induced cardiac oxidative stress by stimulating multiple antioxidant and anti-inflammatory signaling pathways. Scientific Reports, 10, 14459, doi.org/10.1038/s41598-020-71449-1.
36. Nazifa Sifat, S. M. Neamul Kabir Zihad, Farhana Lovely, Razina Rouf, Gazi Mohammad Al Shajib, Md. Ashraful Alam, Jamil A. Shilpi, Shaikh J. Uddin (2020) Supplementation of Heliotropium indicum Linn attenuates obesity and associated metabolic disorders in high carbohydrate high fat diet induced obese rats. Food Biochemistry, 44:e13444. https://doi.org/10.1111/jfbc.13444.
37. Md Mizanur Rahman, Khandoker Usran Ferdous, Shraboni Roy, Iffat Ara Nitul, Fariha Mamun, Md Hemayet Hossain, Nusrat Subhan, Md Ashraful Alam, Md. Areeful Haque, (2020) Polyphenolic compounds of Amla prevents oxidative stress and fibrosis in the kidney and heart of 2K1C rats. Food Science & Nutrition 8(7): 3578–3589. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
38. Salma Khan, Md. Mizanur Rahman, Fariha Kabir, Kamrun Nahar, Fariha Mamun, Shoumen Lasker, Nusrat Subhan, Md. Hemayet Hossain, Lutfun Nahar, Satyajit D. Sarker, Md. Ashraful Alam, Md. Areeful Haque (2020) Trichosanthes dioica Roxb. prevents hepatic inflammation and fibrosis in CCl4-induced ovariectomized rats, Clinical Nutrition Experimental, 33: 1-17. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
39. Nitol Debnath, Farzana Binte Rafique, Nasrin Akhter, Anayt Ulla, Tahmina Yasmin, Md Nurul Islam, Md Ashraful Alam (2020) Supplementation of Psidium guajava leaves powder prevents hepatotoxicity and inflammation in carbon tetrachloride (CCl₄) administered rats. Current Bioactive Compounds DOI : 10.2174/1573407216999200715162928 (accepted). I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
40. Emranul Haque Masum, Hashim Mushtasin Reza, Mohammad Jobaer, Razia Sultana, Md Rafin Hossain, Shamim Hossen, Md Ashraful Alam and MN Islam (2020) Anti-inflammatory, and Anti-nociceptive Properties of Leaf & Root Extracts of Amaranthus spinosus (2020) EC Pharmacology and Toxicology 8.6: 44-51.
41. Fariha Mamun, Mushfera Zamila, Md. Mizanur Rahman, Nusrat Subhan, Hemayet Hossain, S. M. Raquibul Hasan, Md. Ashraful Alam, Md. Areeful Haque (2020) Polyphenolic compounds of litchi leaf augment kidney and heart functions in 2K1C rats, Journal of Functional Food 64: 103662. I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
42. Biswajit Sikder, Farzana Akter, Anayt Ulla, Nusrat Subhan, Md. Iqbal Ahmed, Md Ashraful Alam (2020) HMG-CoA Reductase Inhibitor, Rosuvastatin, Averted Oxidative Stress, Inflammation and Fibrosis in Liver of Carbon Tetrachloride-Induced Rats, Journal of Advanced Biotechnology and Experimental Therapeutics 3(1): 01-08. . I designed the idea of this research, trained the students for executing the research, analyzed the data and drafted the manuscript for submission as corresponding author.
NO |
DEGREE |
INSTITUTION |
YEAR |
AWARD/GRADE |
1 |
PhD |
School of Biomedical Sciences, The University of Queensland, St. Lucia, QLD, Australia. |
2013 |
Awarded |
2 |
MS in Pharmacology |
Department of Pharmacology; Faculty of Veterinary Science. Bangladesh Agricultural University, Mymensingh. |
2006 |
Grade-A GPA-3.906/4 |
3 |
B Pharm. (Hons.) |
Pharmacy Discipline, Life Science School, Khulna University, Bangladesh
|
2003 |
First Class, % of marks obtained-67.07% |
4 |
Higher Secondary Certificate Examination |
Khulna Public College, Khulna.
|
1998 |
Science, First Division, % of marks obtained-70.30%
|
5 |
Secondary School Certificate Examination |
Chalna K.C. Pilot High School, Chalna, Khulna |
1996 |
Science, First Division, % of marks obtained-79.60%
|
Academic Career
RESEARCH WORK DONE IN UDERGRADUATE AND POST GRADUATE LEVEL
1) “Role of natural antioxidants and phenolic compounds in cardiometabolic syndrome” for the fulfillment of the degree PhD (Biomedical Science), The University of Queensland. Supervised by Professor Lindsay Brown, Department of Biological and Physical Sciences, University of Southern Queensland, Australia.
2) “Protein binding nature of the antihypertensive drugs (atenolol and amlodipine) and drug- drug interaction in presence of arsenic” for the partial fulfillment of the degree MS in Pharmacology from Bangladesh Agricultural University. Supervised by Professor Dr. Md Abdul Awal, Department of Pharmacology, Bangladesh Agricultural University, Mymensingh.
3) “Pharmacological investigation of the crude extract of the plant Xylocarpus granatum” for the Partial fulfillment of the degree Bachelor of Pharmacy (Hons.) from Khulna University, Bangladesh. Supervised by Assoc. Professor Mokaddez Sarder, Pharmacy Discipline, Khulna University.
Expertise:
None
Currently teaching
Undergraduate level
Adv. Pharmaceutical Analysis, and Pharmacognosy
Graduate Level
Toxicology and Safety Pharmacology
PROFESSIONAL MEMBERSHIP
REVIEW REQUEST PERFORMED FOR
My lab (under my leadership) is currently doing research on several projects.
1. CCl4 induced cirrhotic liver in rats.
2. 2K1C Goldblatt hypertensive rat model.
3. ISO induced cardiac remodeling in rats.
4. High fat diet induced obesity in rats and natural compounds.
we are currently using Red amaranth (Lal shak), Rice bran, Guava leaves as well as ramipril, sitagliptin, etorocoxib as therapeutic intervention for inflammation and oxidative stress on those experimental model.