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Full Time Faculty Curriculum Vitae |
Dr. Mahbuba Rahman joined the Department of Biochemistry and Microbiology at North South University as an Assistant Professor on July 1st, 2024. She earned her B.Sc. (Honors) and M.Sc. in Microbiology, as well as an M.S. in Environmental Science. She completed her PhD in Metabolic Engineering from the Department of Bioscience and Bioinformatics at Kyushu Institute of Technology, Japan.
After completing her PhD, she worked with a transgenic mouse model of Smith–Lemli–Opitz syndrome, an inborn error of cholesterol synthesis, at the Children's Hospital Research Institute (CHORI) in Oakland, California. Following this, she served as a Postdoctoral Fellow and Staff Scientist at various North American universities and in Qatar.
Dr. Rahman has published numerous research articles, both clinical and non-clinical, and as first author and co-author, in high-impact journals such as the New England Journal of Medicine, Nature Medicine, Cells, and others. She has also authored several review articles and book chapters with prominent publishers. Additionally, she is the editor of two eBooks on cancer immunotherapy and precision vaccinology for infectious diseases, and two books titled Metabolomics: A Path Towards Personalized Medicine and Metabolomics of Personalized Vaccinology. Furthermore, she serves as a special topic editor and guest editor for Frontiers in Genetics, Frontiers in Immunology, and the Journal of Microbiological Methods. She is also a reviewer for several Q1-category journals.
Dr. Rahman also served as an Adjunct Assistant Professor in the Department of Biology at McMaster University, Canada, where she collaborated with an NSERC Alliance grant funded by the Ministry of Environment (MECP) Canada and contributed to publications related to harmful algal blooms in Ontario. In addition, she also took part in guest lecturing, assisted undergraduate students with molecular biology techniques, high-throughput microscopy, and nutrient measurement in wastewater.
Her current research interests include personalized medicine, systems biology, infectious diseases, environmental microbiology, metagenomics, antibiotic resistance, colorectal cancer, and metabolomics.
https://scholar.google.com/citations?user=rPQLop8AAAAJ&hl=en
Publications as NSU faculty
Articles:
1. Lamya F, Arif M, Rahman M, Gul ARZ, Alam T (2025). Machine Learning based Model Reveals the Metabolites Involved in Coronary Artery Disease. Biomedical Engineering and Computational Biology. doi: 10.1177/11795972251352014 (IF: 3.1)
2. Rahman M (2024). Editorial: design considerations for future personalized vaccination approaches. Nanomedicine. doi: 10.1080/17435889.2024.2419816 (IF:6.5)
3. Ogishi M........Rahman M et al., (2024). Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling. Immunity. doi: 10.1016/j.immuni.2024.10.014 (IF:43.47)
Book Chapters:
1. Rahman, M., (2024). “Dendritic cell-based cancer vaccine production”, in Metabolomics for Personalized Vaccinology, Series, Developments in Applied Microbiology and Biotechnology, Editor Mahbuba Rahman. Elsevier Science, Academic Press. doi: 1016/B978-0-443-15526-0.00006-8
2. Rahman, M., (2024). “Vaccines for allergy”, in Metabolomics for Personalized Vaccinology, Series, Developments in Applied Microbiology and Biotechnology, Editor Mahbuba Rahman. Elsevier Science, Academic Press. doi: 1016/B978-0-443-15526-0.00010-X
3. Rahman, M., (2024). “Virus vaccine production using cell based technology”, in Metabolomics for Personalized Vaccinology, Series, Developments in Applied Microbiology and Biotechnology, Editor Mahbuba Rahman. Elsevier Science, Academic Press. doi: 1016/B978-0-443-15526-0.00008-1
4. Rahman, M., (2024). “Technologies to measure vaccine immune response against infectious diseases”, in Metabolomics for Personalized Vaccinology, Series, Developments in Applied Microbiology and Biotechnology, Editor Mahbuba Rahman. Elsevier Science, Academic Press. doi: 1016/B978-0-443-15526-0.00007-X
Book Editor:
Metabolomics for Personalized Vaccinology (1st edition), Series: Developments in Applied Microbiology and Biotechnology (2024). Editor, Mahbuba Rahman Elsevier Science, Academic Press. ISBN: 9780443155260.
Publications with other affiliations:
Research Articles:
1. Saleem F, Jennifer L. JIang JL, ........Rahman M, et al., (2024) Regional and Longitudinal Dynamics of Cyanobacterial Blooms/Cyanobiome and Cyanotoxin Production in the Great Lakes Area. Toxins. doi: 10.3390/toxins16110471 (IF: 4.0)
2. Rahman M, et al (2024) Editorial: Precision Vaccinology for Infectious Diseases. Frontiers in Immunology. doi: 10.3389/fimmu.2024.1400443. (IF:5.9)
3. Rahman M (2023) Magnetic Resonance Imaging and Iron-oxide Nanoparticles in the era of Personalized Medicine. Nanotheranostics doi: 10.7150/ntno.86467 (IF: 3.4)
4. Rahman M and Schellhorn HE (2023) Metabolomics of infectious diseases in the era of personalized medicine. Frontiers in Molecular Biosciences doi: 10.3389/fmolb.2023.1120376. (IF: 4.0)
5. Rosain,J, Neehus AL, Manry J,…….Rahman M, et al. (2023) Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria. Cell doi: 10.1016/j.cell.2022.12.038. (IF: 45.5)
6. Khan TK, Rahman M, et al (2022) Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens. Frontiers in Immunology doi: 10.3389/fimmu.2022.856497. (IF: 5.9)
7. Rahman M, et al. (2022) Editorial: Metabolomics in Infectious Diseases. Frontiers in Genetics. doi: 10.3389/fgene.2022.875835. (IF: 2.8)
8. Guennoun A, Bougarn A, …..Rahman M, et al. (2021) A novel STK4 mutation impairs T cell immunity through dysregulation of cytokine-induced adhesion and chemotaxis genes. Journal of Clinical Immunology doi: 11007/s10875-021-01115-2 (IF: 8.1)
9. Beziat V, Rapaport F,………Rahman M, et al. (2021) Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy. Cell doi: 10.1016/j.cell.2021.06.004 (IF: 45.5)
10. Ogishi M, Yang R, Aytekin C, Langlais D, Bourgey M, Khan T, Al-Ali F, Rahman M, et al.(2021) Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child. Nature Medicine doi: 1038/s41591-021-01388-5 (IF: 82.9)
11. Hasan MR, Rahman M et al. (2021). Virome-wide serological profiling reveals association of herpesviruses with obesity. Scientific Reports doi:1038/s41598-021-82213-4 (IF:3.9)
12. Khan T, Rahman M et al. (2021). Distinct antibody repertoires against endemic human coronaviruses in children and adults. Journal of Clinical Investigation Insight, doi: 1172/jci.insight.144499 (IF: 6.1)
13. Yu A….., Rahman M et al. (2021). Inhibition of nucleophosmin 1 suppresses colorectal cancer tumor growth of patient -derived xenografts via activation of p53 and inhibition of AKT. Cancer Biology & Therapy, doi: 10.1080/15384047.2020.1839278 (IF: 4.6)
14. Yang R,… Rahman M et al. (2020). Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria. Cell doi: 10.1016/j.cell.2020.10.046 (IF: 45.5)
15. Kerner G,……..Rahman M et al. (2020). Inherited human IFN-γ deficiency underlies mycobacterial disease. Journal of Clinical Investigations doi: 1172/jci135460 (IF: 13.6)
16. Drutman SB,……Rahman M, et al. (2020). Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency. New England Journal of Medicine doi: 1056/nejmoa1910640 (IF: 78.5)
17. Weiswald LB, Hasan MR, Wong JC, Pasiliao CC, Rahman M, Ren J, Yin Y,Gusscott S, Vacher S, Weng AP, Kennecke HF,Bieche I, Schaeffer DF, Yapp DT, Tai IT (2017). Inactivation of the Kinase Domain of CDK10 Prevents Tumor Growth in a Preclinical Model of Colorectal Cancer, and Is Accompanied by Downregulation of Bcl-2. Mol Cancer Therapeutics doi: 10.1158/1535-7163.MCT-16-0666. (IF: 5.5)
18. Rahman M and Hasan MR (2015). Cancer metabolism and drug resistance. Metabolites, 5:571-600. (IF: 4.1)
19. Wong JC, Hasan MR, Rahman M, Yu AC, Chan SK, Schaeffer DF, Kennecke HF, Lim HJ, Owen D, Tai IT (2013). Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53-mediated cellular senescence. International Journal of Cancer: 133, 1567-1578. (IF: 4.7)
20. Rahman M, Selvarajan K, Hasan MR, Chan APK, Jin C, Kim J, Chan S, Le ND, Kim YB and Tai IT (2012). Inhibition of COX-2 in colon cancer modulates tumor growth and MDR-1 expression to enhance tumor regression in therapy-refractory cancers in vivo. Neoplasia 14(7):624-633. (IF: 7.7)
21. Rahman M, Chan APK and Tai IT (2011). A peptide of SPARC interferes with the interaction between caspase8 and Bcl2 to resensitize chemoresistant tumors and enhance their regression in vivo. PLOS ONE 6(11): e26390. (IF: 2.6)
22. Matabosch X, Rahman M, Hughes B, Patel SB, Watson G, Shackleton C (2009). Steroid production and excretion by the pregnant mouse, particularly in relation to pregnancies with fetuses deficient in Delta7-sterol reductase (Dhcr7), the enzyme associated with Smith-Lemli-Opitz syndrome. J Steroid Biochem Mol Biol. 116(1-2):61-70. (IF: 5.01)
23. Hasan MR, Rahman M, Jaques S, Purantini E and Daniels L (2009). Glucose-6-phosphate accumulation in mycobacteria: implications for a novel F420- dependent anti-oxidant defense system. Biol. Chem 285(25):19135-44. (IF: 5.4)
24. Rahman M and Shimizu K (2008). Altered acetate metabolism and biomass production in several Escherichia coli mutants lacking rpoS dependent metabolic pathway genes. Mol Biosyst.4(2):160-9. (IF: 2.8)
25. Rahman M, Hasan MR, Shimizu K (2008). Growth-phase dependent changes in the expression of global regulatory genes and associated metabolic pathways in Escherichia coli. Biotechnol Lett. 30(5):853-60. (IF: 2.1)
26. Rahman M, Hasan MR, Ooba T, Shimizu K (2006). The effect of rpoS gene knockout on the metabolism of Escherichia coli during exponential growth phase and early stationary phase based on gene expressions, enzyme activities and intracellular metabolite concentrations. Biotechnol Bioeng. 94:585-95. (IF: 3.6)
27. Rahman M, Rahman MM, Khan SI, Hasan MR, Islam MS (2003). Influence of temperature on the chemotaxis of Vibrio cholerae 0139 towards Anabaena Online J. Biol. Sci. 3:237-246.
Data-note:
Rahman M, Boughorbel S, Presnell S et al. A curated transcriptome dataset collection to investigate the functional programming of human hematopoietic cells in early life. F1000Research 2016, 5:414 (doi: 10.12688/f1000research.8375.1) (IF: 1.39)
Protocol:
Marr AK, Blazkova J, Rahman M et al. Dataset annotation guide for the Gene Expression Browser (GXB). F1000Research 2016 (doi.org/10.7490/f1000research.1112011.1) (IF: 1.39)
Book Chapters:
1. Rahman, M., (2023). “Industrial Application of metabolomics for personalized medicine: Current status and challenges”, in Metabolomics A Path Towards Personalized Medicine, Series, Developments in Applied Microbiology and Biotechnology, Editor Mahbuba Rahman. Elsevier Science, Academic Press. doi: 10.1016/B978-0-323-99924-3.00009-1
2. Szczepski, K., Alyounis, EM., …..Rahman, M. et al. (2023). “Metabolic biomarkers in cancer”, in Metabolomics A Path Towards Personalized Medicine, Series, Developments in Applied Microbiology and Biotechnology, Editor Mahbuba Rahman. Elsevier Science, Academic Press. doi:10.1016/B978-0-323-99924-3.00009-1
3. Rahman, M., et al., (2023). “Metabolomics of diabetes and cardiovascular disease”, in Metabolomics A Path Towards Personalized Medicine, Series, Developments in Applied Microbiology and Biotechnology, Editor Mahbuba Rahman. Elsevier Science, Academic Press. doi: 10.1016/B978-0-323-99924-3.00009-1
4. Rahman, M., and Ramaswamy, M., (2023). “Metabolomics used in clinical diagnosis related to newborn screening”, in Metabolomics A Path Towards Personalized Medicine, Series, Developments in Applied Microbiology and Biotechnology, Editor Mahbuba Rahman. Elsevier Science, Academic Press. doi: 10.1016/B978-0-323-99924-3.00007-8
5. Azad, AK., Hakim, Al., Sohag, MMH., and Rahman. M., (2023). “Metabolomics in clinical diagnosis, prognosis, and treatment of infectious diseases”, in Metabolomics A Path Towards Personalized Medicine, Series, Developments in Applied Microbiology and Biotechnology, Editor Mahbuba Rahman. Elsevier Science, Academic Press. doi: 10.1016/B978-0-323-99924-3.00003-0
6. Rahman, M., (2023). “Metabolomics for Personalized Medicine”, in Metabolomics A Path Towards Personalized Medicine, Series, Developments in Applied Microbiology and Biotechnology, Editor Mahbuba Rahman. Elsevier Science, Academic Press. doi: 10.1016/B978-0-323-99924-3.00006-6
7. Rahman, M. et al. (2014). “Pentose Phosphate Pathway in Disease and Therapy”, in Advanced Materials Research, Editors A. Jafar Mazumder and Amir Al-Ahmed. Trans Tech Publications Inc. doi:10.4028/www.scientific.net/AMR.995.1
8. Rahman, M. (2013). “Medical Applications of Fermentation Technology”, in Advanced Medical Materials Research, Editors A. Jafar Mazumder and Amir Al-Ahmed. Trans Tech Publications Inc. doi: 10.4028/www.scientific.net/AMR.810.127
9. Rahman M., Hasan M. R. (2018) “Synthetic Biopolymers”. Book entitled Functional Biopolymers. Polymers and Polymeric Composites: A Reference Series, Editors, Jafar Mazumder M., Sheardown H., Al-Ahmed A. Springer, Cham.
10. Rahman, M (2015) “Metabolic pathways and chemotherapy drugs”. Book entitled Frontiers in Drug Design and Discovery, Editors, Atta-ur-Rahman Bentham Science Publishers.
11. Rahman, M. (2014) “Application of Metabolic Engineering in Industrial Fermentative Process”. Book entitled Advances in Food Biotechnology. Editor Dr. Ravishankar Rai, John Wiley & Sons, Ltd.
Selected conference proceedings: International:
1. Louis-Bastien Weiswald, Mohammad R Hasan, Mahbuba Rahman, Clarissa Pasiliao, Isabella T Tai. CDK10 promotes tumour growth and chemoresistance in colorectal cancer, and is a potential target for treatment. Conference: American Association for Cancer Research (AACR) 106th Annual Meeting 2015, Held at Philadelphia, PA, USA. Proceedings published in Cancer Research.
2. Mahbuba Rahman, Sharon Gorski, Isabella T. Tai. SPARC Modulates Autophagy via Caspase 8 in the Presence of 5-Fluorouracil in Colorectal Cancer. Conference: Digestive Disease Week (DDW), 2013, Held at Florida, USA. Proceedings published in Gastroenterology.
3. Mahbuba Rahman, Isabella T. Tai. Synergism Between SPARC and Collagen-IV in Promoting Cell Death and/or Growth Inhibition in Colorectal Cancer (CRC) in vitro. Conference: Digestive Disease Week (DDW), 2012, Held at San Diego, California, USA. Proceedings published in Gastroenterology.
4. Mahbuba Rahman, Sharon Gorski, Isabella T. Tai. SPARC Improves the Anti-Tumor Effect of Aspirin in Combination With Chemotherapy in Colorectal Cancers Through Inhibition of Autophagy. Conference: Digestive Disease Week (DDW), 2012, Held at San Diego, California, USA. Proceedings published in Gastroenterology.
5. F. Kennecke, M. Rahman, S. Yip, R. Woods, D. Schaeffer, I. Tai. Effect of nab-rapamycin versus rapamycin in colorectal cancer cell lines and associations with KRAS and PI3K mutations. 2011 American Society of Clinical Oncology (ASCO) Annual Meeting, held at Held in Chicago, Illinois, USA. Proceedings published in the Journal of Clinical Oncology.
Book Editor:
Metabolomics: A Path Towards Personalized Medicine (1st edition), Series: Developments in Applied Microbiology and Biotechnology (2023). Editor, Mahbuba Rahman Elsevier Science, Academic Press. ISBN: 9780323999243.
eBook Precision Vaccinology for Infectious Diseases (2024), Series: Frontiers in Immunology. Editors, Mahbuba Rahman, Mehdi Adeli, Herb E. Schellhorn, Puthen Veettil Jithesh and Ofer levy. Lausanne: Frontiers Media SA. doi: 10.3389/978-2-8325-4847-9.
eBook Systems Biology in Cancer Immunotherapy (Volume 2) (2016). Series: Frontiers in Cancer Immunology. Editor, Mahbuba Rahman Bentham Science Publishers. ISBN: 978-1-68108-308-7
2007 PhD (Biosciences and Bioinformatics),
Kyushu Institute of Technology, Iizuka, Japan.
Thesis title: Metabolic regulation analysis on the roles of the stress responsive global regulatory genes such as rpoS in Escherichia coli at different phases of growth in batch culture.
Advisor: Professor Kazuyuki Shimizu
2002 Master of Environmental Management, Griffith University, Brisbane, Australia.
1998 M.Sc. (Microbiology), University of Dhaka, Dhaka, Bangladesh.
Thesis title: Chemotaxis of Vibrio cholerae 0139 towards Anabaena sp. as influenced by physicochemical parameters.
1995 B.Sc. (Hons. Microbiology), University of Dhaka, Dhaka, Bangladesh.
2024-present Assistant Professor, Department of Biochemistry and Microbiology, North South University, Dhaka, Bangladesh.
2023-present Adjunct Assistant Professor, Department of Biology, McMaster University, Hamilton, ON, Canada (1 year)
2021-2022 Facilitator and Lecturer, REACH program, Novartis, Bangladesh.
2021 Postdoctoral Fellow, Translational Cancer Immunity Center, Biomedical Research Institute (QBRI), Doha, Qatar (8 months)
2015-2020 Staff Scientist, Department of Systems Biology and Immunology, Sidra Medicine, Doha, Qatar ( 5 years 6 months)
2010-2013 Postdoctoral Fellow, Department of Medicine, University of British Columbia at Genome Sciences Centre, BC Cancer Research Centre, Vancouver, BC, Canada ( 3 years 4 months)
2009 Postdoctoral Fellow, Department of Microbiology, University of British Columbia, Vancouver, BC, Canada ( 9 months)
2008 Postdoctoral Research Associate, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, Texas, USA ( 1 year)
2007 Researcher, Children’s Hospital Oakland Research Institute (CHORI), Oakland, California, USA
2006-2007 Research Assistant, Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka, Japan
2001 Laboratory Technician, Microbiological Quality Assurance Laboratory, Cook Australia (a biomedical equipment manufacturing company).
1999-2000 Research Officer, STD Lab, Laboratory Sciences Division (LSD), International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh
1998-1999 Quality Control Officer, Beximco Infusions Ltd., Tongi, Bangladesh
1995-1997 Research Student, Environmental Microbiology Laboratory, LSD, ICDDR,B, Dhaka, Bangladesh.
Bio 202, MIC 314, MIC 309, MIC 207, BIO 202L, BIO 103L, MIC 413L, MIC 415L
Guest Editor: Journal of Microbiological Methods (IF: 1.9)
Reviewer: Molecular Cancer (IF: 37.3)
Reviewer: Frontiers in Immunology (IF: 5.9)
Reviewer: Discover Oncology (F: 2.9)
Reviewer: Hereditas (IF: 2.6)
Book Proposal Reviewer: Elsevier Publishers
Member: The International Society of Bangladesh Affiliated Microbiologists (ISBM)
Member: Dhaka University Microbiology Alumni Association (DUMMA)
Personalized Medicine
Systems Biology
Environmental Microbiology
Metagenomics
Antibiotic resistance
Colorectal cancer
Metabolomics
Infectious Diseases